Vellara Hans R, Ali Noor Q, Gokul Akilesh, Turuwhenua Jason, Patel Dipika V, McGhee Charles N J
Department of Ophthalmology New Zealand National Eye Centre, University of Auckland, Auckland, New Zealand.
School of Optometry and Visual Sciences, University of Auckland, Auckland, New Zealand.
Invest Ophthalmol Vis Sci. 2015 Oct;56(11):6941-7. doi: 10.1167/iovs.15-17396.
To examine and evaluate ocular biomechanical metrics and additionally derived corneal and orbital components using a noncontact Scheimpflug-based tonometer (CorVis ST) in a population of healthy eyes.
A total of 152 eyes of 152 participants were examined by slit-lamp biomicroscopy, corneal tomography, and the CorVis ST (CST). This determined the distribution of outputs from the CST, such as deformation amplitude (DA), and additionally derived parameters, including maximum corneal deformation (MCD), maximum orbital deformation (MOD), and corneal energy dissipation (CED).
The mean age of participants was 35.88 ± 13.8 years. Deformation amplitude significantly correlated with age (r = 0.24, P = 0.002) but not sex or ethnicity (P > 0.05). Multiple linear regression analysis revealed significant correlations between DA and age (r = 0.19, P = 0.006) and DA and IOP (r = -0.59, P < 0.001). Age correlated with MCD (r = 0.20, P = 0.01), MOD (r = 0.18, P = 0.03), and CED (r = 0.39, P < 0.001). Males had a lower MOD than females (0.24 vs. 0.26 mm, respectively, P = 0.01); however, there were no differences in MCD or CED between sexes (P > 0.05). There were no significant differences between ethnicities for MCD, MOD, and CED (P > 0.05). Multiple linear regression analysis revealed significant correlations between MCD and IOP (r = -0.65, P < 0.001), CED and age (r = 0.41, P < 0.001), CED and IOP (r = 0.28, P = 0.001), and between CED and central corneal thickness (CCT) (r = -0.36, P < 0.001).
The isolation of the corneal component (MCD) should be used when analyzing deformation characteristics in diseases that only affect the cornea. This study establishes a baseline for a population of healthy eyes. Future publications will identify differences in MCD, MOD, and CED between healthy and diseased populations.
使用基于非接触式Scheimpflug眼压计（CorVis ST）检查和评估健康人群眼睛的生物力学指标以及额外推导的角膜和眼眶参数。
对152名参与者的152只眼睛进行裂隙灯生物显微镜检查、角膜断层扫描和CorVis ST（CST）检查。这确定了CST输出结果的分布，如变形幅度（DA），以及额外推导的参数，包括最大角膜变形（MCD）、最大眼眶变形（MOD）和角膜能量耗散（CED）。
参与者的平均年龄为35.88±13.8岁。变形幅度与年龄显著相关（r = 0.24，P = 0.002），但与性别或种族无关（P>0.05）。多元线性回归分析显示DA与年龄（r = 0.19，P = 0.006）以及DA与眼压（r = -0.59，P<0.001）之间存在显著相关性。年龄与MCD（r = 0.20，P = 0.01）、MOD（r = 0.18，P = 0.03）和CED（r = 0.39，P<0.001）相关。男性的MOD低于女性（分别为0.24 vs. 0.26 mm，P = 0.01）；然而，性别之间的MCD或CED没有差异（P>0.05）。不同种族之间的MCD、MOD和CED没有显著差异（P>0.05）。多元线性回归分析显示MCD与眼压（r = -0.65，P<0.001）、CED与年龄（r = 0.41，P<0.001）、CED与眼压（r = 0.28，P = 0.001）以及CED与中央角膜厚度（CCT）（r = -0.36，P<0.001）之间存在显著相关性。
在分析仅影响角膜的疾病的变形特征时，应使用角膜成分（MCD）的分离值。本研究为健康人群建立了基线。未来的出版物将确定健康人群和患病人群之间MCD、MOD和CED的差异。
