Department of Nutrition, School of Public Health, Iran University of Medical Sciences, Tehran, Iran.
Nutrition and Food Security Research Center, School of Public Health, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
BMC Endocr Disord. 2023 Jul 3;23(1):136. doi: 10.1186/s12902-023-01364-9.
Previous studies have shown that insulin directly affects the risk of type 2 diabetes mellitus (T2DM) but the relationship between insulinaemic potential of diet and lifestyle and the T2DM risk is still unknown. Accordingly, we aimed to investigate the relationship between the insulinaemic potential of diet and lifestyle based on indices including empirical dietary index for hyperinsulinaemia (EDIH), empirical lifestyle index for hyperinsulinaemia (ELIH), empirical dietary index for insulin resistance (EDIR) and empirical lifestyle index for insulin resistance (ELIR) and the T2DM risk in the Iranian adults.
This study was performed on data of enrollment phase of the Yazd Health Study (YaHS) and TAghzieh Mardom-e-Yazd (Yazd Nutrition Study) (TaMYZ) on 5714 adults aged 20-70 years (mean: 36.29 years). A validated food frequency questionnaire and clinical tests were used to assess food intake and T2DM ascertainment, respectively. We used the Cox regression analysis for determining the relationship between the indices and T2DM risk.
After adjusting for confounding variables, our findings showed that diet with higher ELIH score is 2.28 times more likely for T2DM risk (RR 2.28 [95% CI 1.69-2.56]), but there was no significant relationship between the EDIH, ELIR and EDIR scores and T2DM risk in adults, in the entire study population.
Our findings suggest that diets with higher ELIH score increases the T2DM risk, but there was no significant relationship between the EDIH, ELIR and EDIR scores and T2DM risk. Further epidemiological studies are needed to confirm our findings.
先前的研究表明胰岛素直接影响 2 型糖尿病（T2DM）的风险，但饮食和生活方式的胰岛素生成潜力与 T2DM 风险之间的关系尚不清楚。因此，我们旨在研究基于包括高胰岛素血症经验性饮食指数（EDIH）、高胰岛素血症经验性生活方式指数（ELIH）、胰岛素抵抗经验性饮食指数（EDIR）和胰岛素抵抗经验性生活方式指数（ELIR）等指标的饮食和生活方式的胰岛素生成潜力与伊朗成年人 T2DM 风险之间的关系。
本研究基于 Yazd 健康研究（YaHS）和 TAghzieh Mardom-e-Yazd（Yazd 营养研究）（TaMYZ）的入组阶段的数据进行，共纳入 5714 名年龄在 20-70 岁（平均：36.29 岁）的成年人。使用经过验证的食物频率问卷和临床检测分别评估食物摄入和 T2DM 确定情况。我们使用 Cox 回归分析来确定指数与 T2DM 风险之间的关系。
在调整了混杂变量后，我们的研究结果表明，高 ELIH 评分的饮食与 T2DM 风险增加 2.28 倍（RR 2.28 [95% CI 1.69-2.56]）有关，但在整个研究人群中，EDIH、ELIR 和 EDIR 评分与 T2DM 风险之间没有显著关系。
我们的研究结果表明，高 ELIH 评分的饮食会增加 T2DM 的风险，但 EDIH、ELIR 和 EDIR 评分与 T2DM 风险之间没有显著关系。需要进一步的流行病学研究来证实我们的发现。
