Farhadnejad Hossein, Mokhtari Ebrahim, Teymoori Farshad, Sohouli Mohammad Hassan, Moslehi Nazanin, Mirmiran Parvin, Azizi Fereidoun
Nutrition and Endocrine Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Department of Nutrition, School of Public Health, Iran University of Medical Sciences, Tehran, Iran.
Nutr J. 2021 Apr 23;20(1):39. doi: 10.1186/s12937-021-00697-2.
We aimed to assess the associations between insulinemic potential of diet and lifestyle and the risk of diabetes incident, using four empirical indices including the empirical dietary index for hyperinsulinemia (EDIH), the empirical dietary index for insulin resistance (EDIR), empirical lifestyle index for hyperinsulinemia (ELIH), and empirical lifestyle index for insulin resistance (ELIR).
A total of 3734 individuals, aged ≥ 20 years old, who were free of diabetes at baseline (2008-2011), were followed for 6.2 years (2015-2018) to ascertain incident diabetes. The food frequency questionnaire was used to collect dietary intakes at baseline. Odds ratio (OR) of diabetes were calculated across quartiles of EDIH, EDIR, ELIH, and ELIR using logistic regression, which controlled for confounding factors.
The mean ± SD age and BMI of individuals (45.1 % male) were 40.9 ± 12.0 years and 27.1 ± 4.1 kg/m, respectively. At the end of follow-up, 253 (6.8 %) diabetes cases were identified. In the multivariable-adjusted model, individuals in the highest quartile of EDIR (1.58;95 %CI:1.03-2.44, P for trend = 0.025), ELIH (1.89;95 %CI:1.20-2.97, P for trend = 0.004), and ELIR (1.74; 95 %CI:1.11-2.72, P for trend = 0.031) had increased the risk of diabetes. However, no significant associations were found between the score of EDIH and diabetes incident.
Higher adherence to EDIR, ELIH, and ELIR scores were associated with increased risk of diabetes, while no significant association was found between EDIH score and diabetes incident.
我们旨在利用四个实证指标，即高胰岛素血症实证饮食指数（EDIH）、胰岛素抵抗实证饮食指数（EDIR）、高胰岛素血症实证生活方式指数（ELIH）和胰岛素抵抗实证生活方式指数（ELIR），评估饮食和生活方式的胰岛素生成潜力与糖尿病发病风险之间的关联。
共有3734名年龄≥20岁、在基线期（2008 - 2011年）无糖尿病的个体，随访6.2年（2015 - 2018年）以确定糖尿病发病情况。使用食物频率问卷在基线期收集饮食摄入量。采用逻辑回归计算EDIH、EDIR、ELIH和ELIR四分位数的糖尿病比值比（OR），并对混杂因素进行控制。
个体（45.1%为男性）的平均年龄±标准差和体重指数分别为40.9±12.0岁和27.1±4.1kg/m²。随访结束时，确定了253例（6.8%）糖尿病病例。在多变量调整模型中，EDIR最高四分位数的个体（1.58；95%CI：1.03 - 2.44，趋势P = 0.025）、ELIH（1.89；95%CI：1.20 - 2.97，趋势P = 0.004）和ELIR（1.74；95%CI：1.11 - 2.72，趋势P = 0.031）患糖尿病的风险增加。然而，未发现EDIH得分与糖尿病发病之间存在显著关联。
更高地遵循EDIR、ELIH和ELIR得分与糖尿病风险增加相关，而未发现EDIH得分与糖尿病发病之间存在显著关联。
