Clinic of Maxillofacial Surgery, Head-Neck and NeuroScience Department University Hospital of Udine, 33100 Udine, Italy.
Department of Plastic Surgery, University Hospital of Udine, 33100 Udine, Italy.
Front Biosci (Landmark Ed). 2023 Jun 27;28(6):123. doi: 10.31083/j.fbl2806123.
Facial reconstruction represents one of the main challenges for surgeons. Stem cells (SC) represent the most studied solution for tissue regeneration. This approach appears particularly promising in combination with bioengineered scaffolds and 3D bioprinting. The purpose of this systematic review is to define the main domains of current application of SC therapy within contemporary clinical workflows, evaluate indications and limitations, report current knowledge in this innovative field of research, and define the landscape of evidence for such approaches.
A systematic review was performed on the pertinent literature regarding stem cell-based cell therapies currently available in the reconstruction of the face. The review used the main databases for scientific literature based on the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines.
A total of 15 papers were selected after an independent search was performed. The two major domains for current application of stem cells in clinical practice were bone and skin categories.
Cell therapy in the field of facial reconstruction represents a promising approach. The evidence regarding the current clinical use, however, seems to show this option to be limited. Bioengineering advances and the parallel development of 3D bioprinting technology can potentially enhance the role of stem cells in the future.
面部重建是外科医生面临的主要挑战之一。干细胞 (SC) 是组织再生研究最多的解决方案。这种方法与生物工程支架和 3D 生物打印相结合似乎特别有前途。本系统评价的目的是确定当前 SC 治疗在当代临床工作流程中的主要应用领域，评估其适应证和局限性，报告该创新研究领域的现有知识，并确定此类方法的证据状况。
对目前可用于面部重建的基于干细胞的细胞治疗相关文献进行了系统评价。该评价根据系统评价和荟萃分析的首选报告项目 (PRISMA) 指南，使用了主要的科学文献数据库。
经过独立搜索，共选择了 15 篇论文。目前干细胞在临床实践中的两个主要应用领域是骨骼和皮肤。
细胞疗法在面部重建领域是一种很有前途的方法。然而，目前关于临床应用的证据似乎表明这种选择是有限的。生物工程的进步和 3D 生物打印技术的并行发展可能会增强干细胞在未来的作用。
