Institute of Radiology and Interventionism, Alpha Imagen, Quito, Ecuador.
ECVIEW International, Biomedical Engineering Department, Mindray, Quito, Ecuador.
Front Endocrinol (Lausanne). 2023 Jun 16;14:1182557. doi: 10.3389/fendo.2023.1182557. eCollection 2023.
A prospective cross-sectional investigation of 170 thyroid nodules (TN) between January 2020 and December 2021 at Alpha Imagen was conducted to determine cut-off points (C/O) for elastography measurements and their diagnostic accuracy.
Nodules were categorized by ACR TI-RADS, Alpha Score (AS), and Bethesda; all were evaluated using 2D Shear Wave Real Time Elastography (RT-SWE), point Shear Wave (pSWE), and Strain Elastography (SE). Data was assessed with ROC curves, the Shapiro-Wilk test, T test, Chi-square test, and ANOVA.
C/O were as follows: RTSWE Emax of 115kPa and 6.5 m/s, Emean of 47.5 kPa and 4.1 m/s, pSWE (average) of 52.4 kpa and 4.15 m/s; sensitivity of 81.2% and specificity of 57.6%, with a PPV of 72.4% and NPV of 70.0%. SE Value A had a C/O of 0.20%, with a sensitivity of 84%, specificity of 57%, PPV of 72.4% and NPP of 73.6%. The Strain Ratio nodule/tissue C/O was calculated as 2.69, with a sensitivity of 84%, specificity of 57%, PPV of 72.3%, and NPV of 73.5%. The RLBIndex quality control must be at least 92%; for pSWE, we suggest a mean interquartile ratio of ≤15.7% for kPa and 8.1% for m/s. The recommended depth is between 1.2 and 1.5 cm, and commonly used ROI boxes were 3x3 and 5x5mm.
2D-SWE and pSWE with Emax and Emean demonstrated C/O with excellent diagnostic accuracy. To maximize the correct classification of TN, we suggest combining ACR TI-RADS and AS with any of the elastography measurements assessed here.
对 2020 年 1 月至 2021 年 12 月在 AlphaImagen 进行的 170 个甲状腺结节（TN）进行前瞻性横断面研究，以确定弹性成像测量的截止值（C/O）及其诊断准确性。
根据 ACR TI-RADS、Alpha 评分（AS）和 Bethesda 对结节进行分类；所有结节均使用二维剪切波实时弹性成像（RT-SWE）、单点剪切波（pSWE）和应变弹性成像（SE）进行评估。使用 ROC 曲线、Shapiro-Wilk 检验、T 检验、卡方检验和方差分析对数据进行评估。
C/O 如下：RTSWE Emax 为 115kPa 和 6.5m/s，Emean 为 47.5kPa 和 4.1m/s，pSWE（平均）为 52.4kPa 和 4.15m/s；敏感性为 81.2%，特异性为 57.6%，阳性预测值为 72.4%，阴性预测值为 70.0%。SE 值 A 的 C/O 为 0.20%，敏感性为 84%，特异性为 57%，阳性预测值为 72.4%，阴性预测值为 73.6%。结节/组织的应变比 C/O 计算为 2.69，敏感性为 84%，特异性为 57%，阳性预测值为 72.3%，阴性预测值为 73.5%。RLBIndex 质量控制必须至少为 92%；对于 pSWE，我们建议 kPa 的中值四分位比≤15.7%，m/s 的中值四分位比≤8.1%。建议的深度在 1.2 到 1.5 厘米之间，常用的 ROI 框为 3x3 和 5x5mm。
二维 SWE 和 pSWE 及其 Emax 和 Emean 具有出色的诊断准确性。为了最大程度地正确分类 TN，我们建议将 ACR TI-RADS 和 AS 与这里评估的任何一种弹性成像测量方法结合使用。
