Kantharaj Vimalraj, Yoon Young-Eun, Lee Keum-Ah, Choe Hyeonji, Chohra Hadjer, Seo Woo Duck, Kim Young-Nam, Lee Yong Bok
Institute of Agriculture and Life Science (IALS), Gyeongsang National University, Jinju 52828, Republic of Korea.
Division of Applied Life Science (BK21), Gyeongsang National University, Jinju 52828, Republic of Korea.
ACS Omega. 2023 Jun 14;8(25):22285-22295. doi: 10.1021/acsomega.3c00267. eCollection 2023 Jun 27.
Saponarin (SA) is a major di--glycosyl--glycosyl flavone, which is predominantly accumulated in the young green leaves of barley ( L.), with numerous biological functions in plants, such as protection against environmental stresses. Generally, SA synthesis and its localization in the mesophyll vacuole or leaf epidermis are largely stimulated in response to biotic and abiotic stresses to participate in a plant's defense response. In addition, SA is also credited for its pharmacological properties, such as the regulation of signaling pathways associated with antioxidant and anti-inflammatory responses. In recent years, many researchers have shown the potential of SA to treat oxidative and inflammatory disorders, such as in protection against liver diseases, and reducing blood glucose, along with antiobesity effects. This review aims to highlight natural variations of SA in plants, biosynthesis pathway, and SA's role in response to environmental stress and implications in various therapeutic applications. In addition, we also discuss the challenges and knowledge gaps concerning SA use and commercialization.
皂草苷（SA）是一种主要的二糖基-糖基黄酮，主要积累在大麦（Hordeum vulgare L.）的幼嫩绿叶中，在植物中具有多种生物学功能，如抵御环境胁迫。一般来说，响应生物和非生物胁迫时，SA的合成及其在叶肉液泡或叶表皮中的定位会受到很大刺激，以参与植物的防御反应。此外，SA还因其药理特性而受到认可，如调节与抗氧化和抗炎反应相关的信号通路。近年来，许多研究人员已表明SA在治疗氧化和炎症性疾病方面的潜力，如预防肝脏疾病、降低血糖以及具有抗肥胖作用。本综述旨在强调植物中SA的自然变异、生物合成途径，以及SA在应对环境胁迫中的作用和在各种治疗应用中的意义。此外，我们还讨论了SA使用和商业化方面的挑战和知识空白。
