Furukawa F, Haebara H, Hamashima Y
Acta Pathol Jpn. 1986 May;36(5):773-81. doi: 10.1111/j.1440-1827.1986.tb01065.x.
A 12-year-old Japanese girl with a primary intracranial choriocarcinoma arising from the pituitary fossa is reported. There was a markedly high level of serum human chorionic gonadotropin (HCG) throughout the clinical course. Postmortem examination revealed metastatic lesions found in the cerebellum, dura mater, skull (clivus, sphenoidal bone), and lungs. Immunohistochemical characteristics of the primary intracranial tumor and lung lesions disclosed positive stainings for HCG and HCG-beta in the neoplastic syncytiotrophoblastic cells.
报告了一名12岁日本女孩，其原发性颅内绒毛膜癌起源于垂体窝。在整个临床过程中，血清人绒毛膜促性腺激素（HCG）水平显著升高。尸检发现小脑、硬脑膜、颅骨（斜坡、蝶骨）和肺部有转移病灶。原发性颅内肿瘤和肺部病灶的免疫组织化学特征显示，肿瘤合体滋养层细胞中HCG和HCG-β呈阳性染色。
