Bhushan Arya, Gonsalves Andrea, Menon Jyothi U
Ladue Horton Watkins High School, St. Louis, MO 63124, USA.
Department of Biomedical and Pharmaceutical Sciences, College of Pharmacy, University of Rhode Island, Kingston, RI 02881, USA.
Pharmaceutics. 2021 May 14;13(5):723. doi: 10.3390/pharmaceutics13050723.
Breast cancer is one of the leading causes of cancer-related morbidity and mortality in women worldwide. Early diagnosis and effective treatment of all types of cancers are crucial for a positive prognosis. Patients with small tumor sizes at the time of their diagnosis have a significantly higher survival rate and a significantly reduced probability of the cancer being fatal. Therefore, many novel technologies are being developed for early detection of primary tumors, as well as distant metastases and recurrent disease, for effective breast cancer management. Theranostics has emerged as a new paradigm for the simultaneous diagnosis, imaging, and treatment of cancers. It has the potential to provide timely and improved patient care via personalized therapy. In nanotheranostics, cell-specific targeting moieties, imaging agents, and therapeutic agents can be embedded within a single formulation for effective treatment. In this review, we will highlight the different diagnosis techniques and treatment strategies for breast cancer management and explore recent advances in breast cancer theranostics. Our main focus will be to summarize recent trends and technologies in breast cancer diagnosis and treatment as reported in recent research papers and patents and discuss future perspectives for effective breast cancer therapy.
乳腺癌是全球女性癌症相关发病和死亡的主要原因之一。对所有类型癌症进行早期诊断和有效治疗对于良好的预后至关重要。诊断时肿瘤体积较小的患者生存率显著更高，癌症致命的概率也显著降低。因此，正在开发许多新技术用于早期检测原发性肿瘤、远处转移和复发性疾病，以实现有效的乳腺癌管理。治疗诊断学已成为一种用于同时诊断、成像和治疗癌症的新范式。它有潜力通过个性化治疗及时改善患者护理。在纳米治疗诊断学中，细胞特异性靶向部分、成像剂和治疗剂可以嵌入单一制剂中以实现有效治疗。在本综述中，我们将重点介绍乳腺癌管理的不同诊断技术和治疗策略，并探索乳腺癌治疗诊断学的最新进展。我们的主要重点将是总结近期研究论文和专利中报道的乳腺癌诊断和治疗的最新趋势和技术，并讨论有效乳腺癌治疗的未来前景。
