• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

Mechano-sensitive TET1s inhibits endothelial athero-susceptible phenotype through regulating YAP phosphorylation.

作者信息

Huang Lu, Qu Kai, Wang Caihong, Lei Daoxi, Yan Wenhua, Li Tianhan, Hou Zhengjun, Qiu Juhui, Wang Guixue

机构信息

Key Laboratory for Biorheological Science and Technology of Ministry of Education, State and Local Joint Engineering Laboratory for Vascular Implants, Bioengineering College of Chongqing University, Chongqing 400030, China.

School of Advanced Manufacturing Engineering, Chongqing University of Posts and Telecommunications, Chongqing 400065, China.

出版信息

Genes Dis. 2023 Apr 4;10(4):1183-1186. doi: 10.1016/j.gendis.2023.01.029. eCollection 2023 Jul.

DOI:10.1016/j.gendis.2023.01.029
PMID:37397553
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10311081/
Abstract
摘要

相似文献

1
Mechano-sensitive TET1s inhibits endothelial athero-susceptible phenotype through regulating YAP phosphorylation.机械敏感的TET1s通过调节YAP磷酸化来抑制内皮细胞的动脉粥样硬化易感表型。
Genes Dis. 2023 Apr 4;10(4):1183-1186. doi: 10.1016/j.gendis.2023.01.029. eCollection 2023 Jul.
2
TET1s deficiency exacerbates oscillatory shear flow-induced atherosclerosis.TET1s 缺乏加剧振荡剪切流诱导的动脉粥样硬化。
Int J Biol Sci. 2022 Feb 28;18(5):2163-2180. doi: 10.7150/ijbs.69281. eCollection 2022.
3
YAP and the RhoC regulator ARHGAP18, are required to mediate flow-dependent endothelial cell alignment.YAP 和 RhoC 调节因子 ARHGAP18 是介导流动依赖性内皮细胞排列所必需的。
Cell Commun Signal. 2020 Feb 3;18(1):18. doi: 10.1186/s12964-020-0511-7.
4
Flow-dependent YAP/TAZ activities regulate endothelial phenotypes and atherosclerosis.血流依赖性YAP/TAZ活性调节内皮细胞表型和动脉粥样硬化。
Proc Natl Acad Sci U S A. 2016 Oct 11;113(41):11525-11530. doi: 10.1073/pnas.1613121113. Epub 2016 Sep 26.
5
MicroRNA-10a regulation of proinflammatory phenotype in athero-susceptible endothelium in vivo and in vitro.MicroRNA-10a 在体内和体外调节易损动脉粥样硬化内皮的促炎表型。
Proc Natl Acad Sci U S A. 2010 Jul 27;107(30):13450-5. doi: 10.1073/pnas.1002120107. Epub 2010 Jul 12.
6
Role of flow-sensitive microRNAs in endothelial dysfunction and atherosclerosis: mechanosensitive athero-miRs.血流敏感型微小RNA在内皮功能障碍和动脉粥样硬化中的作用：机械敏感型动脉粥样硬化微小RNA
Arterioscler Thromb Vasc Biol. 2014 Oct;34(10):2206-16. doi: 10.1161/ATVBAHA.114.303425. Epub 2014 Jul 10.
7
Arterial endothelial methylome: differential DNA methylation in athero-susceptible disturbed flow regions in vivo.动脉内皮甲基化组：体内动脉粥样硬化易损性紊乱血流区域的DNA甲基化差异
BMC Genomics. 2015 Jul 7;16:506. doi: 10.1186/s12864-015-1656-4.
8
Endothelial protein kinase C isoform identity and differential activity of PKCzeta in an athero-susceptible region of porcine aorta.猪主动脉易患动脉粥样硬化区域内皮细胞蛋白激酶C亚型的特性及PKCζ的差异活性
Circ Res. 2005 Sep 2;97(5):443-9. doi: 10.1161/01.RES.0000179767.37838.60. Epub 2005 Jul 28.
9
G3BP2 regulates oscillatory shear stress-induced endothelial dysfunction.G3BP2调节振荡剪切应力诱导的内皮功能障碍。
Genes Dis. 2021 Nov 19;9(6):1701-1715. doi: 10.1016/j.gendis.2021.11.003. eCollection 2022 Nov.
10
Atheroprotective laminar flow inhibits Hippo pathway effector YAP in endothelial cells.具有动脉粥样硬化保护作用的层流抑制内皮细胞中的Hippo信号通路效应因子YAP。
Transl Res. 2016 Oct;176:18-28.e2. doi: 10.1016/j.trsl.2016.05.003. Epub 2016 May 26.

引用本文的文献

1
Deciphering Mitochondria: Unveiling Their Roles in Mechanosensing and Mechanotransduction.解读线粒体：揭示其在机械传感和机械转导中的作用。
Research (Wash D C). 2025 Aug 8;8:0816. doi: 10.34133/research.0816. eCollection 2025.
2
[Hot Topics and Emerging Trends in Mechanobiology Research].[力学生物学研究的热点与新趋势]
Sichuan Da Xue Xue Bao Yi Xue Ban. 2024 Jan 20;55(1):1-5. doi: 10.12182/20240160104.

本文引用的文献

1
Isoforms Differentially Regulate Gene Expression, Synaptic Transmission, and Memory in the Mammalian Brain.同种型差异调节哺乳动物大脑中的基因表达、突触传递和记忆。
J Neurosci. 2021 Jan 27;41(4):578-593. doi: 10.1523/JNEUROSCI.1821-20.2020. Epub 2020 Dec 1.
2
A novel isoform of TET1 that lacks a CXXC domain is overexpressed in cancer.一种缺乏CXXC结构域的新型TET1亚型在癌症中过表达。
Nucleic Acids Res. 2017 Aug 21;45(14):8269-8281. doi: 10.1093/nar/gkx435.
3
Integrin-YAP/TAZ-JNK cascade mediates atheroprotective effect of unidirectional shear flow.整合素-YAP/TAZ-JNK级联反应介导单向剪切流的抗动脉粥样硬化作用。
Nature. 2016 Dec 22;540(7634):579-582. doi: 10.1038/nature20602. Epub 2016 Dec 7.
4
Isoform Switch of TET1 Regulates DNA Demethylation and Mouse Development.TET1 异构体转换调控 DNA 去甲基化和小鼠发育。
Mol Cell. 2016 Dec 15;64(6):1062-1073. doi: 10.1016/j.molcel.2016.10.030. Epub 2016 Dec 1.
5
Flow-dependent YAP/TAZ activities regulate endothelial phenotypes and atherosclerosis.血流依赖性YAP/TAZ活性调节内皮细胞表型和动脉粥样硬化。
Proc Natl Acad Sci U S A. 2016 Oct 11;113(41):11525-11530. doi: 10.1073/pnas.1613121113. Epub 2016 Sep 26.