Department of Clinical Studies (Freitag, Valverde, Jensen, Sanchez, Gomez) and Department of Biomedical Sciences (Bailey), Ontario Veterinary College, University of Guelph, Guelph, Ontario N1G 2W1.
Can J Vet Res. 2023 Jul;87(3):217-223.
The objective of this study was to compare the rostral spread of lumbosacral epidural volumes of a mixture of dye and contrast medium, calculated using body weight (BW) or vertebral column length (LE), in 22 dog cadavers. The dogs weighed 4.6 to 52.0 kg. Dogs were paired within a < 10% difference for BW and LE and with the same body condition score (BCS). Pairs of dogs were injected while in sternal recumbency through an epidural catheter with a volume mixture of iopamidol and dye, calculated based on BW: 0.2 mL/kg in one of the cadavers and based on LE: 0.05 mL/cm (< 50 cm), 0.07 mL/cm (50 to < 70 cm), 0.08 mL/cm (70 to < 80 cm), and 0.11 mL/cm (≥ 80 cm) in the other cadaver. The extent of rostral spread was determined using computed tomography for iopamidol and anatomical dissection for dye. Comparisons for dye and iopamidol within each dog, and for BW and LE within matched pairs, were completed with mixed linear models ( < 0.05). The number of vertebrae reached by dye was greater than the number reached by iopamidol in both BW and LE, but the rostral spread was not significantly different between BW and LE for all pairs. In conclusion, dye tends to spread further than iopamidol and therefore, these two methods should not be considered interchangeable when used in research studies.
本研究旨在比较 22 具犬尸体中使用体重（BW）或脊柱长度（LE）计算的染料和对比剂混合物的腰骶部硬膜外容积的头侧扩散情况。这些犬的体重为 4.6 至 52.0 公斤。在 BW 和 LE 相差不超过 10%的范围内对犬进行配对，并具有相同的身体状况评分（BCS）。通过硬膜外导管向犬成对注射碘帕醇和染料的体积混合物，根据 BW 计算：一具尸体中每只犬注射 0.2 mL/kg，另一具尸体中根据 LE 计算：0.05 mL/cm（<50cm）、0.07 mL/cm（50 至 <70cm）、0.08 mL/cm（70 至 <80cm）和 0.11 mL/cm（≥80cm）。使用计算机断层扫描（CT）确定碘帕醇的头侧扩散范围，使用解剖学方法确定染料的头侧扩散范围。使用混合线性模型（<0.05）完成每只犬内的染料和碘帕醇之间以及配对内的 BW 和 LE 之间的比较。在 BW 和 LE 中，染料达到的椎骨数量均多于碘帕醇，但所有配对中 BW 和 LE 之间的头侧扩散无显著差异。总之，与碘帕醇相比，染料倾向于扩散得更远，因此，在研究中使用这两种方法时不应将其视为可互换。
