Baghaffar Mariam H, Samargandy Shaza
Internal Medicine, King Abdulaziz University Faculty of Medicine, Jeddah, SAU.
Endocrinology, King Abdulaziz University Faculty of Medicine, Jeddah, SAU.
Cureus. 2023 Jun 1;15(6):e39829. doi: 10.7759/cureus.39829. eCollection 2023 Jun.
Graves' disease (GD) is an immune-mediated condition related to high thyroid-stimulating immunoglobulin levels. Here, we present a rare case of recurrent thyrotoxicosis that developed in a thyroglossal duct cyst (TGDC) and the residual thyroid tissue in a 46-year-old female following subtotal thyroidectomy. In 2005, she was diagnosed with GD causing thyrotoxicosis and treated with subtotal thyroidectomy. In 2022, she was seen at our clinic with a neck swelling gradually growing in size over the last 10 years. On examination, the mass was found to be moving with tongue protrusion. She was on thyroxin 100 mcg daily, and the dose was reduced gradually until she was maintained on no therapy for hypothyroidism and was still thyrotoxic. The combined clinical, laboratory thyroid scintigraphy and ultrasonographic features favored early developing recurrent Graves' disease in the thyroid residual and TGDC. She was started on carbimazole and was referred for surgery. Our case represents a rare occurrence of recurrent GD in the thyroid residual and TGDC.
格雷夫斯病（GD）是一种与高甲状腺刺激免疫球蛋白水平相关的免疫介导性疾病。在此，我们报告一例罕见的复发性甲状腺毒症病例，该病例发生在一名46岁女性的甲状舌管囊肿（TGDC）及甲状腺次全切除术后残留的甲状腺组织中。2005年，她被诊断为GD导致的甲状腺毒症，并接受了甲状腺次全切除术。2022年，她因颈部肿胀前来我院就诊，该肿胀在过去10年中逐渐增大。检查发现肿块随伸舌动作移动。她每天服用100微克甲状腺素，剂量逐渐减少，直至维持不进行甲状腺功能减退治疗，但仍处于甲状腺毒症状态。综合临床、实验室甲状腺闪烁扫描及超声检查特征，提示甲状腺残留组织及TGDC早期出现复发性格雷夫斯病。她开始服用卡比马唑，并被转诊接受手术治疗。我们的病例代表了甲状腺残留组织及TGDC中罕见的复发性GD病例。
