Yang Hui, Wang Shaowen, Wang Jie, Xu Xiangsheng, Li Xiaoqing
College of Chemical Engineering, Zhejiang University of Technology, Hangzhou 310014, P. R. China.
Chem Commun (Camb). 2023 Jul 20;59(59):9078-9081. doi: 10.1039/d3cc02275g.
The hydroxyl group was discovered to promote gold catalyzed hydrofluorination of alkynes hydrogen bonding interaction. Based on this strategy, propargyl alcohols could be hydrofluorinated smoothly using EtN·3HF under acidic additive-free conditions, which provided a straightforward alternative protocol for the synthesis of 3-fluoroallyl alcohols.
发现羟基通过氢键相互作用促进金催化的炔烃氢氟化反应。基于此策略，在无酸性添加剂的条件下，使用EtN·3HF可顺利实现炔丙醇的氢氟化反应，这为3-氟烯丙醇的合成提供了一种直接的替代方法。
