Department of Biostatistics, Biostatistics Program, School of Public Health, Louisiana State University Health, New Orleans, Louisiana, USA.
Department of Oral and Craniofacial Biology, Louisiana State University Health, School of Dentistry, New Orleans, Louisiana, USA.
Clin Exp Dent Res. 2023 Aug;9(4):721-732. doi: 10.1002/cre2.762. Epub 2023 Jul 4.
HIV disease is evolving with more HIV+ persons experiencing a high quality of life with well-controlled viremia. We recently enrolled a large cohort of HIV+ and clinically relevant HIV- persons for oral microbiome analyses that included a questionnaire related to oral hygiene and recreational behaviors. Here, the questionnaire responses were analyzed for behavioral trends within the cohort, together with trends over time by comparison to a previous geographically centered HIV+ cohort.
Data were collected by questionnaire at baseline visits as cross-sectional assessments. Multivariable analyses were conducted for associations of HIV status as well as age, race, and sex, on oral hygiene/recreational behaviors.
HIV+ subjects had reduced brushing frequency, but increased incidence of past cleanings and frequency of dry mouth, compared to the HIV- subjects. Within the entire cohort, positive associations were identified between age and several oral hygiene practices, and between age, race, and sex for several recreational behaviors. In comparison to the historical cohort, the contemporary HIV+ cohort participated in fewer high-risk behaviors, but with similar trends for smoking and oral hygiene practices.
HIV status had little association with oral hygiene and recreational behaviors despite several differences in age, race, and sex. Behavioral trends over time support a higher quality of life in people currently living with HIV.
随着越来越多 HIV 阳性患者的病毒得到良好控制，生活质量得到提高，HIV 疾病也在不断演变。我们最近招募了大量 HIV 阳性和具有临床相关性的 HIV 阴性个体进行口腔微生物组分析，其中包括与口腔卫生和娱乐行为相关的问卷。在这里，我们对问卷的回答进行了分析，以了解队列中的行为趋势，并与之前以地理位置为中心的 HIV 阳性队列进行了时间趋势比较。
通过问卷在基线访视时进行横断面评估来收集数据。采用多变量分析方法，分析了 HIV 状态以及年龄、种族和性别与口腔卫生/娱乐行为之间的关联。
与 HIV 阴性个体相比，HIV 阳性个体刷牙频率较低，但过去洁牙的频率和口干的频率较高。在整个队列中，年龄与几种口腔卫生习惯之间存在正相关关系，年龄、种族和性别与几种娱乐行为之间也存在正相关关系。与历史队列相比，当代 HIV 阳性队列参与的高风险行为较少，但吸烟和口腔卫生习惯的趋势相似。
尽管在年龄、种族和性别方面存在差异，但 HIV 状态与口腔卫生和娱乐行为的相关性不大。随着时间的推移，行为趋势表明，目前生活在 HIV 感染中的人们生活质量更高。
