Kaşkal Mert, Sevim Mustafa, Ülker Gökay, Keleş Caner, Bebitoğlu Berna Terzioğlu
Department of Pharmacology, School of Medicine, Marmara University, Istanbul, Turkey.
Department of Physiology, School of Medicine, Marmara University, Istanbul, Turkey.
Naunyn Schmiedebergs Arch Pharmacol. 2025 Jan 10. doi: 10.1007/s00210-025-03788-7.
One of the goals of clinical pharmacology is to optimize patient treatment by adopting new treatment strategies which will increase the efficacy of the treatment and decrease the adverse effects of the drugs. In the literature, it has shown that the effectiveness and toxicity of medications can vary significantly based on when they are administered, making timing a crucial factor in treatment plans. Chronopharmacology a relatively new branch of clinical pharmacology focuses on adjusting drug administration times to enhance patient outcomes. Chronopharmacology is largely influenced by an individual's circadian rhythm which refers to periodic changes in biological processes depending on the time of the day. The chronopharmacology influences clinical practice, and the accumulating knowledge in this field will likely lead healthcare providers to adopt new strategies for drug treatment regimens. This review aims to summarize the impact of chronopharmacology particularly on current clinical practices and highlight the latest findings related to chronophysiological mechanisms.
临床药理学的目标之一是通过采用新的治疗策略来优化患者治疗，这些策略将提高治疗效果并减少药物的不良反应。文献表明，药物的有效性和毒性会因给药时间的不同而有显著差异，这使得给药时间成为治疗方案中的关键因素。时辰药理学是临床药理学中一个相对较新的分支，专注于调整给药时间以改善患者预后。时辰药理学在很大程度上受个体昼夜节律的影响，昼夜节律是指生物过程根据一天中的时间而发生的周期性变化。时辰药理学影响临床实践，该领域不断积累的知识可能会促使医疗保健提供者采用新的药物治疗方案策略。本综述旨在总结时辰药理学特别是对当前临床实践的影响，并突出与时辰生理机制相关的最新发现。
