Pan Renjie, Chen Dongdong, Hou Lanlan, Hu Rong, Jiao Zhigang
First Clinical Medical College, Gannan Medical University, Ganzhou, Jiangxi, China.
Laboratory Medicine, First Affiliated Hospital of Gannan Medical University, Ganzhou, Jiangxi, China.
Front Aging Neurosci. 2023 Jun 19;15:1184435. doi: 10.3389/fnagi.2023.1184435. eCollection 2023.
Neurodegenerative diseases (NDs) have a slow onset and are usually detected late during disease. NDs are often difficult to cure due to the presence of the blood-brain barrier (BBB), which makes it difficult to find effective treatments and drugs, causing great stress and financial burden to families and society. Currently, small extracellular vesicles (sEVs) are the most promising drug delivery systems (DDSs) for targeted delivery of molecules to specific sites in the brain as a therapeutic vehicle due to their low toxicity, low immunogenicity, high stability, high delivery efficiency, high biocompatibility and trans-BBB functionality. Here, we review the therapeutic application of sEVs in several NDs, including Alzheimer's disease, Parkinson's disease, and Huntington's disease, discuss the current barriers associated with sEVs and brain-targeted DDS, and suggest future research directions.
神经退行性疾病（NDs）起病缓慢，通常在疾病晚期才被发现。由于血脑屏障（BBB）的存在，NDs往往难以治愈，这使得寻找有效的治疗方法和药物变得困难，给家庭和社会带来了巨大的压力和经济负担。目前，小细胞外囊泡（sEVs）作为一种治疗载体，因其低毒性、低免疫原性、高稳定性、高递送效率、高生物相容性和穿越血脑屏障的功能，是将分子靶向递送至脑内特定部位最有前景的药物递送系统（DDSs）。在此，我们综述了sEVs在几种神经退行性疾病中的治疗应用，包括阿尔茨海默病、帕金森病和亨廷顿病，讨论了与sEVs和脑靶向DDS相关的当前障碍，并提出了未来的研究方向。
