Tatullo Marco, Marrelli Benedetta, Facente Anastasia, Paduano Francesco, Qutachi Omar
Department of Translational Biomedicine and Neuroscience - DiBraiN, University of Bari "Aldo Moro", P. ce G. Cesare, 70124, Italy.
School of Dentistry, University of Dundee, Dundee, UK.
Heliyon. 2024 Aug 8;10(16):e36038. doi: 10.1016/j.heliyon.2024.e36038. eCollection 2024 Aug 30.
Addressing the growing challenges of periodontal and peri-implant diseases, this study first reports a promising advancement in precision dentistry: an intricately formulated biopolymer spray designed for precise, localized drug delivery during tailored dental procedures. Poly (lactic--glycolic acid) (PLGA), recognized for its controlled release, biodegradability, and FDA-approved biocompatibility, forms the core of this formulation. Utilizing the double emulsion method, PLGA microparticles (PLGA-MPs) were loaded with dental antibiotics: sodium amoxicillin (AMX-Na), trihydrate amoxicillin (AMX-Tri), and metronidazole (Met). This antibiotic combination was thoughtfully selected to meet the distinctive requirements of the most impacting dental treatments. The newly developed biopolymer spray underwent thorough in-vitro analysis, revealing an optimized release curve for antibiotics over time, guaranteeing sustained therapeutic efficacy, and dose-dependent efficacy, accommodating personalized treatment approaches. The positive outcomes position the novel biopolymer spray formulation the leaders in advancing localized drug delivery during dental procedures. Moreover, the precise application and the tunable formulation meets the concept of precision medicine: in detail, this formulation represents a significant stride in dental therapeutics, significantly contributing to the predictability of dental implantology.
为应对牙周病和种植体周围疾病日益严峻的挑战，本研究首次报道了精准牙科领域一项颇具前景的进展：一种精心配制的生物聚合物喷雾剂，专为在定制牙科手术期间进行精确的局部药物递送而设计。聚乳酸-乙醇酸共聚物（PLGA）因其控释性、生物可降解性以及获得美国食品药品监督管理局（FDA）批准的生物相容性而闻名，它构成了该制剂的核心。利用双乳液法，将牙科抗生素：阿莫西林钠（AMX-Na）、三水合阿莫西林（AMX-Tri）和甲硝唑（Met）负载到PLGA微粒（PLGA-MPs）中。精心选择这种抗生素组合以满足最具影响力的牙科治疗的独特需求。新开发的生物聚合物喷雾剂经过了全面的体外分析，结果显示抗生素随时间推移呈现出优化的释放曲线，确保了持续的治疗效果以及剂量依赖性疗效，适应个性化治疗方法。这些积极成果使新型生物聚合物喷雾剂制剂在推动牙科手术期间的局部药物递送方面处于领先地位。此外，精确的应用和可调节的制剂符合精准医学的概念：具体而言，这种制剂代表了牙科治疗学的一项重大进展，对牙种植学的可预测性做出了重大贡献。
