Wu Zhijian, Xie Feng, Li Kai, Feng Jie, Han Leilei, Wu Yanqing
Department of Cardiology, The Second Affiliated Hospital of Nanchang University, Nanchang, China.
Front Cardiovasc Med. 2023 Jun 19;10:1182731. doi: 10.3389/fcvm.2023.1182731. eCollection 2023.
hypertension is one of the major preventable risk factors for numerous diseases. The role of vitamin E in blood pressure (BP) has been controversial. We aimed to investigate the relationship between gamma-tocopherol serum concentration (GTSC) and BP.
Data from 15,687 US adults from the National Health and Nutrition Examination Survey (NHANES) were analyzed. The correlations of GTSC with systolic BP (SBP), diastolic BP (DBP), and prevalence of hypertension were investigated by multivariate logistic regression models, generalized summation models, and fitted smoothing curves. Subgroup analyses were performed to investigate possible effect modifiers between them.
With each natural log increase in GTSC, SBP, and DBP increased by 1.28 mmHg ( 1.28, 95% CI 0.71-1.84) and 1.15 mmHg ( 1.15, 95% CI 0.72-1.57), respectively, both for trend < 0.001; the prevalence of hypertension increased by 12% (OR 1.12, 95% CI 1.03-1.22), for trend 0.008. In subgroup analysis, in drinkers, with each natural log increase in GTSC, SBP, and DBP increased by 1.77 mmHg ( 1.77,95% CI 1.13-2.41) and 1.37 mmHg ( 1.37,95% CI 0.9-1.85), respectively, whereas they were not correlated in non-drinkers.
GTSC was linearly and positively associated with SBP, DBP, and the prevalence of hypertension, and alcohol consumption may modify the relationship of GTSC with SBP and DBP.
高血压是多种疾病主要的可预防风险因素之一。维生素E在血压（BP）方面的作用一直存在争议。我们旨在研究γ-生育酚血清浓度（GTSC）与血压之间的关系。
对来自美国国家健康与营养检查调查（NHANES）的15687名美国成年人的数据进行分析。通过多变量逻辑回归模型、广义相加模型和拟合平滑曲线研究GTSC与收缩压（SBP）、舒张压（DBP）以及高血压患病率之间的相关性。进行亚组分析以研究它们之间可能的效应修饰因素。
GTSC每自然对数增加，SBP和DBP分别升高1.28 mmHg（1.28，95%可信区间0.71 - 1.84）和1.15 mmHg（1.15，95%可信区间0.72 - 1.57），二者趋势均<0.001；高血压患病率增加12%（比值比1.12，95%可信区间1.03 - 1.22），趋势P = 0.008。在亚组分析中，在饮酒者中，GTSC每自然对数增加，SBP和DBP分别升高1.77 mmHg（1.77，95%可信区间1.13 - 2.41）和1.37 mmHg（1.37，95%可信区间0.9 - 1.85），而在不饮酒者中它们不相关。
GTSC与SBP、DBP以及高血压患病率呈线性正相关，饮酒可能改变GTSC与SBP和DBP之间的关系。
