Department of Clinical Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences (TUMS), Tehran, Iran.
Nutritional Health Research Center, Lorestan University of Medical Sciences, Khorramabad, Iran.
J Hum Hypertens. 2019 Jul;33(7):499-507. doi: 10.1038/s41371-019-0192-0. Epub 2019 Mar 7.
Although emerging evidence suggests that vitamin E may contribute to blood pressure improvement, the effects of vitamin E on systolic blood pressure (SBP), diastolic blood pressure (DBP), and mean arterial pressure (MAP) are still controversial. The aim was to evaluate the influence of vitamin E on SBP, DBP, and MAP through meta-analysis. We identified all studies that assessed the effect of vitamin E supplementation on SBP, DBP, and MAP from PubMed/Medline, SCOPUS, and Google scholar up to March 2018. Weighted mean differences (WMD) and 95% confidence interval (CI) were expressed as effect size. Pre-specified subgroup analysis was conducted to evaluate potential sources of heterogeneity. Meta-regression analyses were performed to investigate association between blood pressure-lowering effects of vitamin E and duration of follow-up and dose of treatment. Eighteen trials, comprising 839 participants met the eligibility criteria. Results of this study showed that compared to placebo, SBP decreased significantly in vitamin E group (WMD = -3.4 mmHg, 95% CI = -6.7 to -0.11, P < 0.001), with a high heterogeneity across the studies (I = 94.0%, P < 0.001). Overall, there were no significant effects on DBP and MAP. This meta-analysis suggested that vitamin E supplements decreased only SBP and had no favorable effect on DBP and MAP.
尽管新出现的证据表明维生素 E 可能有助于改善血压，但维生素 E 对收缩压（SBP）、舒张压（DBP）和平均动脉压（MAP）的影响仍存在争议。本研究旨在通过荟萃分析评估维生素 E 对 SBP、DBP 和 MAP 的影响。我们从 PubMed/Medline、SCOPUS 和 Google scholar 数据库中检索了截至 2018 年 3 月评估维生素 E 补充剂对 SBP、DBP 和 MAP 影响的所有研究。采用加权均数差（WMD）和 95%置信区间（CI）表示效应量。进行了预先指定的亚组分析以评估异质性的潜在来源。进行了荟萃回归分析以研究维生素 E 降压效果与随访时间和治疗剂量之间的关系。符合纳入标准的有 18 项试验，共纳入 839 名参与者。研究结果表明，与安慰剂相比，维生素 E 组 SBP 显著降低（WMD = -3.4mmHg，95% CI = -6.7 至 -0.11，P < 0.001），但研究间存在高度异质性（I = 94.0%，P < 0.001）。总体而言，维生素 E 对 DBP 和 MAP 没有显著影响。本荟萃分析表明，维生素 E 补充剂仅降低 SBP，对 DBP 和 MAP 没有有利影响。
