Li Xiaoping, Xu Chuang, Liang Bingchun, Kastelic John P, Han Bo, Tong Xiaofang, Gao Jian
Department of Clinical Veterinary Medicine, College of Veterinary Medicine, China Agricultural University, Beijing, China.
Faculty of Veterinary Medicine, University of Calgary, Calgary, AB, Canada.
Front Vet Sci. 2023 Jun 19;10:1160350. doi: 10.3389/fvets.2023.1160350. eCollection 2023.
Mastitis is considered the costliest disease on dairy farms and also adversely affects animal welfare. As treatment (and to a lesser extent prevention) of mastitis rely heavily on antibiotics, there are increasing concerns in veterinary and human medicine regarding development of antimicrobial resistance. Furthermore, with genes conferring resistance being capable of transfer to heterologous strains, reducing resistance in strains of animal origin should have positive impacts on humans. This article briefly reviews potential roles of non-steroidal anti-inflammatory drugs (NSAIDs), herbal medicines, antimicrobial peptides (AMPs), bacteriophages and their lytic enzymes, vaccination and other emerging therapies for prevention and treatment of mastitis in dairy cows. Although many of these approaches currently lack proven therapeutic efficacy, at least some may gradually replace antibiotics, especially as drug-resistant bacteria are proliferating globally.
乳腺炎被认为是奶牛场代价最高昂的疾病，并且还会对动物福利产生不利影响。由于乳腺炎的治疗（以及在较小程度上的预防）严重依赖抗生素，兽医和人类医学领域对抗菌素耐药性的发展越来越担忧。此外，由于赋予耐药性的基因能够转移到异源菌株，降低动物源菌株中的耐药性应该会对人类产生积极影响。本文简要综述了非甾体抗炎药（NSAIDs）、草药、抗菌肽（AMPs）、噬菌体及其裂解酶、疫苗接种以及其他新兴疗法在预防和治疗奶牛乳腺炎方面的潜在作用。尽管目前这些方法中的许多都缺乏已证实的治疗效果，但至少其中一些可能会逐渐取代抗生素，尤其是在全球耐药细菌不断扩散的情况下。
