Townes B D, Dikmen S S, Bledsoe S W, Hornbein T F, Martin D C, Janesheski J A
Anesth Analg. 1986 Sep;65(9):955-9.
We investigated the effect of controlled hypotension during halothane anesthesia on brain functions as measured by neuropsychological tests. Anesthesia in 17 patients included controlled hypotension, whereas in another 27 patients hypotension was not induced during surgery for correction of facial abnormalities. Intraoperative EEG recording showed no significant changes in EEG power during the induction of hypotension. Hypotensive anesthesia was not associated with greater postoperative impairment than normotensive anesthesia. Both groups did show short-term postoperative impairment of memory and learning. For at least the first 24 hrs after administration of a general anesthetic agent such as halothane, there is interference with consolidation of memory. This impairment was not apparent in follow-up examinations 6 months later.
我们通过神经心理学测试研究了氟烷麻醉期间控制性低血压对脑功能的影响。17例患者的麻醉包括控制性低血压，而另外27例患者在面部畸形矫正手术期间未诱导低血压。术中脑电图记录显示，低血压诱导期间脑电图功率无显著变化。与正常血压麻醉相比，低血压麻醉术后并未出现更严重的损伤。两组患者术后均出现短期记忆和学习障碍。在给予氟烷等全身麻醉剂后的至少头24小时内，存在对记忆巩固的干扰。这种损伤在6个月后的随访检查中并不明显。
