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凋亡诱导因子：一种与代谢性疾病相关的线粒体蛋白——综述

Apoptosis-inducing factor: a mitochondrial protein associated with metabolic diseases-a narrative review.

作者信息

Zong Liang, Liang Zhou

机构信息

College of Otolaryngology Head and Neck Surgery, Chinese PLA General Hospital, Beijing, China.

National Clinical Research Center for Otolaryngologic Diseases, Beijing, China.

出版信息

Cardiovasc Diagn Ther. 2023 Jun 30;13(3):609-622. doi: 10.21037/cdt-23-123. Epub 2023 Jun 19.

DOI:10.21037/cdt-23-123
PMID:37405018
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10315422/
Abstract

BACKGROUND AND OBJECTIVE

Apoptosis-inducing factor (AIF), a flavin protein in mitochondria, is originally found to induce apoptosis under the stimulation of pro-apoptotic factors. As a mitochondrial flavin adenine dinucleotide-dependent oxidoreductase, AIF is involved in the regulation of mammalian cell metabolism by regulating respiratory enzyme activity, antioxidant stress, promoting mitochondrial autophagy and glucose uptake, etc. Herein, we focused on the research progress regarding the molecular mechanism of AIF in metabolic mediation and the recent research on AIF in metabolic diseases, as well as the AIF-mediated apoptotic process.

METHODS

Articles for this paper were obtained by reviewing the literature related to the role of AIF in metabolic diseases on PubMed. The search terms included the following: "apoptosis", "metabolism" or "metabolic diseases" plus "apoptosis-inducing factor". The titles, abstracts, and full texts of relevant English-language publications published from October 1996 to June 2022 were manually screened to clarify the role of AIF in metabolic diseases.

KEY CONTENT AND FINDINGS

We found that AIF played an important role in a variety of metabolically-related diseases, such as diabetes, obesity, metabolic syndrome, and tumor metabolism, by mediating apoptosis.

CONCLUSIONS

We summarized the important role of AIF in a variety of metabolic diseases, which might help to further expand the understanding of AIF and to develop AIF-related therapeutic targets.

摘要

背景与目的

凋亡诱导因子（AIF）是一种线粒体中的黄素蛋白，最初发现其在促凋亡因子刺激下可诱导细胞凋亡。作为一种线粒体黄素腺嘌呤二核苷酸依赖性氧化还原酶，AIF通过调节呼吸酶活性、抗氧化应激、促进线粒体自噬和葡萄糖摄取等参与哺乳动物细胞代谢的调控。在此，我们聚焦于AIF在代谢介导中的分子机制研究进展、AIF在代谢性疾病中的最新研究以及AIF介导的凋亡过程。

方法

通过在PubMed上检索与AIF在代谢性疾病中的作用相关的文献获取本文所需文章。检索词包括：“凋亡”“代谢”或“代谢性疾病”加上“凋亡诱导因子”。对1996年10月至2022年6月发表的相关英文出版物的标题、摘要和全文进行人工筛选，以阐明AIF在代谢性疾病中的作用。

关键内容与发现

我们发现AIF通过介导凋亡在多种代谢相关疾病中发挥重要作用，如糖尿病、肥胖症、代谢综合征和肿瘤代谢。

结论

我们总结了AIF在多种代谢性疾病中的重要作用，这可能有助于进一步拓展对AIF的认识并开发与AIF相关的治疗靶点。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1f1a/10315422/157a3b033be2/cdt-13-03-609-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1f1a/10315422/02f51da8ca71/cdt-13-03-609-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1f1a/10315422/157a3b033be2/cdt-13-03-609-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1f1a/10315422/02f51da8ca71/cdt-13-03-609-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1f1a/10315422/157a3b033be2/cdt-13-03-609-f2.jpg

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