Xie Keyu, Cheng Xu, Zhu Tao, Zhang Donghang
Department of Anesthesiology, West China Hospital, Sichuan University, Chengdu, China.
Department of Anesthesiology, Chengdu Second People's Hospital, Chengdu, China.
Front Neuroanat. 2023 Jun 19;17:1162049. doi: 10.3389/fnana.2023.1162049. eCollection 2023.
The somatosensory neurons in the dorsal root ganglion (DRG) are responsible to detect peripheral physical and noxious stimuli, and then transmit these inputs into the central nervous system. DRG neurons are composed of various subpopulations, which are suggested to respond to different stimuli, such as mechanical, thermal, and cold perception. For a long time, DRG neurons were classified based on anatomical criteria. Recently, single-cell (scRNA-seq) and single-nucleus RNA-sequencing (snRNA-seq) has advanced our understanding of the composition and functional heterogeneity of both human and rodent DRG neurons at single-cell resolution. In this review, we summarized the current literature regarding single-cell transcriptomic profiling of DRG to provide an integral understanding in the molecular transcriptomes, cell types, and functional annotations of DRG neurons in humans and rodents.
背根神经节（DRG）中的躯体感觉神经元负责检测外周的物理和有害刺激，然后将这些输入传递到中枢神经系统。DRG神经元由各种亚群组成，这些亚群被认为对不同的刺激有反应，如机械、热和冷觉。长期以来，DRG神经元是根据解剖学标准进行分类的。最近，单细胞（scRNA-seq）和单细胞核RNA测序（snRNA-seq）使我们在单细胞分辨率水平上对人和啮齿动物DRG神经元的组成和功能异质性有了更深入的了解。在这篇综述中，我们总结了当前关于DRG单细胞转录组分析的文献，以便全面了解人和啮齿动物DRG神经元的分子转录组、细胞类型和功能注释。
