90 岁以上“长寿老人”C-反应蛋白参考区间的探索。

Exploration for the reference interval of C-reactive protein in the Chinese longevity people over 90 years of age.

机构信息

The Key Laboratory of Geriatrics, Beijing Institute of Geriatrics, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing Hospital/National Center of Gerontology of National Health Commission, Beijing, 100730, PR China; Peking University Fifth School of Clinical Medicine (Beijing Hospital), Beijing, 100730, PR China.

出版信息

Diabetes Metab Syndr. 2023 Aug;17(8):102817. doi: 10.1016/j.dsx.2023.102817. Epub 2023 Jun 30.

DOI:10.1016/j.dsx.2023.102817

PMID:37406418

Abstract

BACKGROUND

Older individuals tend to develop chronic inflammation. As a commonly used nonspecific inflammatory marker, C-reactive protein (CRP) can predict metabolic syndrome, cardiovascular diseases, etc. However, little is known about CRP levels in longevity people.

OBJECTIVES

Investigate the distribution and correlates of CRP and provide a reference for the establishment of normal interval values in Chinese longevity people over 90 years of age.

METHODS

We performed a correlation analysis to evaluate the correlation between CRP levels and longevity based on the basic demographic characteristics, anthropometric measurements and blood data of 4,418 participants in the 2015 China Health and Retirement Longitudinal Study and 636 participants in an ongoing longitudinal study of natural longevity people in Guangxi. On this basis, the CRP reference interval for longevity was explored.

RESULTS

The CRP concentration was significantly different among the three age groups, with a median of 3.80 mg/L for those older than 90 years, which was significantly higher than that for those aged 45-64 years (median 1.20 mg/L, p < 0.001) and 65-89 years (median 1.30 mg/L, p < 0.001). Body mass index, waist circumference, the waist-to-height ratio, systolic blood pressure, diastolic blood pressure, and fasting and postprandial blood glucose, triglyceride, total cholesterol and low-density lipoprotein cholesterol levels were positively correlated with CRP levels, while fasting high-density lipoprotein cholesterol was negatively correlated with CRP levels. The CRP reference interval (RI) value in longevity people was 0.25-9.22 mg/L.

CONCLUSION

The concentrations of CRP increased with advancing age, and the CRP reference interval was different between older and younger adults.

摘要

背景

老年人往往会出现慢性炎症。作为一种常用的非特异性炎症标志物，C 反应蛋白（CRP）可以预测代谢综合征、心血管疾病等。然而，关于长寿人群中 CRP 水平的信息知之甚少。

目的

调查 CRP 的分布及其相关性，为建立中国 90 岁以上长寿人群 CRP 的正常参考区间提供参考。

方法

我们基于 2015 年中国健康与退休纵向研究的 4418 名参与者和广西正在进行的自然长寿人群纵向研究的 636 名参与者的基本人口统计学特征、人体测量学测量和血液数据，进行相关性分析，以评估 CRP 水平与长寿之间的相关性。在此基础上，探讨了长寿人群 CRP 的参考区间。

结果

CRP 浓度在 3 个年龄组之间存在显著差异，90 岁以上组的中位数为 3.80mg/L，明显高于 45-64 岁组（中位数 1.20mg/L，p<0.001）和 65-89 岁组（中位数 1.30mg/L，p<0.001）。体质指数、腰围、腰高比、收缩压、舒张压、空腹和餐后血糖、三酰甘油、总胆固醇和低密度脂蛋白胆固醇水平与 CRP 水平呈正相关，而空腹高密度脂蛋白胆固醇与 CRP 水平呈负相关。长寿人群的 CRP 参考区间（RI）值为 0.25-9.22mg/L。