Department of Health Statistics, Second Military Medical University, Shanghai, China.
Dis Markers. 2010;28(6):333-42. doi: 10.3233/DMA-2010-0713.
C-reactive protein (CRP) levels vary remarkably with ethnic status. Its distribution and correlates should be investigated across diverse populations, and these were limited in a representative Chinese population. We investigated 3133 participants aged 18-80 years in Shanghai, which were sampled using a randomized, stratified, multi-stage sampling method. The distribution of CRP was highly skewed toward a lower level. The median CRP was 0.55 mg/L (0.61 mg/L in males, 0.51 mg/L in females). Participants living in urban region had higher CRP levels than those in rural region (0.67 vs. 0.46 mg/L). CRP levels showed significant correlation with traditional cardiovascular risk factors, and it was most strongly correlated with body mass index. Multivariate logistic regression analyses indicated that elevated CRP (being in the top 15 percentile of CRP; CRP > or =2.09 mg/L) was significantly associated with obesity, hypertension, diabetes, low high-density lipoprotein cholesterol, high low-density lipoprotein cholesterol, high triglycerides and cardiovascular disease history. In conclusion, the distribution of CRP in adult Chinese was comparable with that of many other Asian populations but different from that of Western populations. Metabolic impairment was associated with elevated CRP, and CRP levels should be interpreted in conjunction with the lipid profile.
C 反应蛋白（CRP）水平随种族状态而显著变化。应在不同人群中调查 CRP 的分布及其相关性，而这在代表性的中国人群中是有限的。我们调查了上海 3133 名年龄在 18-80 岁的参与者，采用随机、分层、多阶段抽样方法进行抽样。CRP 的分布高度偏向低值。CRP 的中位数为 0.55 毫克/升（男性为 0.61 毫克/升，女性为 0.51 毫克/升）。居住在城区的参与者的 CRP 水平高于农村地区的参与者（0.67 与 0.46 毫克/升）。CRP 水平与传统心血管危险因素显著相关，与体重指数的相关性最强。多元逻辑回归分析表明，CRP 升高（处于 CRP 前 15%；CRP>或=2.09 毫克/升）与肥胖、高血压、糖尿病、低高密度脂蛋白胆固醇、高低密度脂蛋白胆固醇、高三酰甘油和心血管疾病史显著相关。总之，成年中国人的 CRP 分布与许多其他亚洲人群相似，但与西方人群不同。代谢损害与 CRP 升高相关，应结合血脂谱解读 CRP 水平。
