Laboratory of Molecular Neuro-oncology, The Rockefeller University, 1230 York Avenue, New York, NY, 10065, USA.
Bioinformatics Resource Center, The Rockefeller University, 1230 York Avenue, New York, NY, 10065, USA.
Nat Commun. 2023 Jul 5;14(1):3956. doi: 10.1038/s41467-023-39652-6.
The ability to use blood to predict the outcomes of Parkinson's disease, including disease progression and cognitive and motor complications, would be of significant clinical value. We undertook bulk RNA sequencing from the caudate and putamen of postmortem Parkinson's disease (n = 35) and control (n = 40) striatum, and compared molecular profiles with clinical features and bulk RNA sequencing data obtained from antemortem peripheral blood. Cognitive and motor complications of Parkinson's disease were associated with molecular changes in the caudate (stress response) and putamen (endothelial pathways) respectively. Later and earlier-onset Parkinson's disease were molecularly distinct, and disease duration was associated with changes in caudate (oligodendrocyte development) and putamen (cellular senescence), respectively. Transcriptome patterns in the postmortem Parkinson's disease brain were also evident in antemortem peripheral blood, and correlated with clinical features of the disease. Together, these findings identify molecular signatures in Parkinson's disease patients' brain and blood of potential pathophysiologic and prognostic importance.
利用血液预测帕金森病的结果（包括疾病进展和认知及运动并发症）将具有重要的临床价值。我们对帕金森病（n=35）和对照组（n=40）死后纹状体的尾状核和壳核进行了 bulk RNA 测序，并将分子谱与临床特征以及从生前外周血获得的 bulk RNA 测序数据进行了比较。帕金森病的认知和运动并发症分别与尾状核（应激反应）和壳核（血管内皮途径）的分子变化相关。晚发性和早发性帕金森病在分子上是不同的，疾病持续时间分别与尾状核（少突胶质细胞发育）和壳核（细胞衰老）的变化相关。帕金森病患者死后大脑中的转录组模式也存在于生前外周血中，并与疾病的临床特征相关。总之，这些发现确定了帕金森病患者大脑和血液中具有潜在病理生理和预后重要性的分子特征。
