October University for Modern Sciences and Arts, Faculty of Pharmacy, Analytical Chemistry Department, 11787, 6th October City, Egypt.
Analytical Chemistry Department, Faculty of Pharmacy, Cairo University, El-Kasr-El Aini St, 11562, Cairo, Egypt.
Anal Methods. 2023 Jul 20;15(28):3439-3448. doi: 10.1039/d3ay00852e.
Nutraceuticals are promoted and marketed with the stated label of being natural as well as safe herbal products. In order to enhance their effectiveness, nutraceuticals are usually adulterated with undeclared constituents. Slimming herbs may contain sibutramine (SBT) which is an FDA-banned ingredient due to its fatal outcomes. This current work's aim is to design a trimodal sensor for SBT detection in different herbal slimming formulations. Screen-printed silver and multi-walled carbon nanotube inks were employed for the potentiometric sensor. The sensor was designed to fill a reaction well in which a carbon dot-silver nanoparticle pair was applied for fluorimetric and colorimetric purposes. The trimodal sensor was designed to fit an 8 mm 2-pin LED strip connector. Potentiometric measurement took place upon application of one sample aliquot then the optical reaction proceeded next in a specified zone for optical detection. These multiple detection mechanisms achieved the required selectivity for SBT determination in the presence of other slimming products' additives. This trimodal sensor satisfied World Health Organization standards for point-of-care devices demonstrating the suggested device as a dynamic part for rapid on-site detection of undisclosed SBT.
营养保健品以天然、安全的草药产品为宣传卖点进行推广和营销。为了提高其效果，营养保健品通常会掺杂未申报的成分。减肥草药可能含有西布曲明（SBT），由于其致命后果，美国食品和药物管理局已禁止该成分。本研究旨在设计一种用于不同草药减肥配方中西布曲明检测的三模态传感器。采用丝网印刷银和多壁碳纳米管油墨制造用于电位传感器。该传感器设计用于填充一个反应腔，其中应用了一个碳点-银纳米粒子对用于荧光和比色目的。三模态传感器设计为适合 8 毫米 2 引脚 LED 条连接器。施加一份样品等分试样后进行电位测量，然后在指定区域进行光学反应以进行光学检测。这些多种检测机制实现了在其他减肥产品添加剂存在的情况下对 SBT 测定的所需选择性。该三模态传感器符合世界卫生组织对即时护理设备的标准，表明该设备是快速现场检测未申报 SBT 的动态部件。
