Department of Emergency Medicine Chonnam National University Hospital, Chonnam National University Medical School, Gwangju, Korea.
Ulus Travma Acil Cerrahi Derg. 2023 Jul;29(7):752-757. doi: 10.14744/tjtes.2023.40033.
The majority of traumatic brain injury (TBI) cases result in death in the early phase; predicting short-term progno-sis of affected patients is necessary to prevent this. This study aimed to examine the association between the lactate-to-albumin ratio (LAR) on admission and outcomes in the early phase of TBI.
This retrospective observational study included patients with TBI who visited our emergency department between January 2018 and December 2020. TBI was considered as an head abbreviated injury scale (AIS) score of 3 or higher and other AIS of 2 or lower. The primary and secondary outcomes were 24-h mortality and massive transfusion (MT), respectively.
In total, 460 patients were included. The 24-h mortality was 12.6% (n=28) and MT was performed in 31 (6.7%) patients. In the multivariable analysis, LAR was associated with 24-h mortality (odds ratio [OR], 2.021; 95% confidence interval [CI], 1.301-3.139) and MT (OR, 1.898; 95% CI, 1.288-2.797). The areas under the curve of LAR for 24-h mortality and MT were 0.805 (95% CI, 0.766-0.841) and 0.735 (95% CI, 0.693-0.775), respectively.
LAR was associated with early-phase outcomes in patients with TBI, including 24-h mortality and MT. LAR may help predict these outcomes within 24 h in patients with TBI.
大多数创伤性脑损伤（TBI）病例在早期导致死亡；因此，预测受影响患者的短期预后对于预防这种情况是必要的。本研究旨在研究入院时乳酸/白蛋白比值（LAR）与 TBI 早期结局之间的关系。
这是一项回顾性观察性研究，纳入了 2018 年 1 月至 2020 年 12 月期间在我院急诊科就诊的 TBI 患者。TBI 被定义为头部损伤严重程度评分（AIS）为 3 或更高，且其他部位 AIS 为 2 或更低。主要和次要结局分别为 24 小时死亡率和大量输血（MT）。
共纳入 460 例患者。24 小时死亡率为 12.6%（n=28），31 例（6.7%）患者行 MT。多变量分析显示，LAR 与 24 小时死亡率（优势比[OR]，2.021；95%置信区间[CI]，1.301-3.139）和 MT（OR，1.898；95% CI，1.288-2.797）相关。LAR 预测 24 小时死亡率和 MT 的曲线下面积分别为 0.805（95% CI，0.766-0.841）和 0.735（95% CI，0.693-0.775）。
LAR 与 TBI 患者的早期结局相关，包括 24 小时死亡率和 MT。LAR 可能有助于预测 TBI 患者 24 小时内的这些结局。
