Cheng Ying-Lien, Lee Ting-I, Chien Yu-Mei, Lee Ting-Wei, Chen Yi-Jen
Division of Endocrinology and Metabolism, Department of Internal Medicine, Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan.
Division of Endocrinology and Metabolism, Department of Internal Medicine, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan.
Endocr Connect. 2023 Aug 2;12(9):e230013. doi: 10.1530/EC-23-0013.
Vitamin D deficiency is associated with hyperlipidemia, but it remains unclear whether vitamin D supplementation reduces serum lipid levels. The aims of this study were to investigate the associations between increased serum 25-hydroxyvitamin D (25(OH)D) concentrations and lipid levels and identify the characteristics of people with or without lipid reduction associated with increased 25(OH)D levels. The medical records of 118 individuals (53 men; mean age, 54.4 ± 10.6 years) whose serum 25(OH)D levels increased between 2 consecutive measurements were retrospectively reviewed. People with increased 25(OH)D levels (from 22.7 (17.6-29.2) to 32.1 (25.6-36.8) mg/dL; P < 0.01) had a significant reduction in serum levels of triglycerides (TGs) (from 111.0 (80-164) to 104.5 (73-142) mg/dL; P < 0.01) and total cholesterol (TC) (from 187.5 (155-213) to 181.0 (150-210) mg/dL; P < 0.05). The individuals who responded to vitamin D (≥10% reduction in TG or TC levels) exhibited significantly higher baseline TG and TC levels than those who did not. Only patients with hyperlipidemia (not those without hyperlipidemia) at baseline exhibited significantly reduced TG and TC levels at follow-up. However, increasing serum 25(OH)D concentrations were significantly correlated with decreasing lipid levels in individuals with baseline 25(OH)D levels less than 30 ng/mL and in individuals aged 50-65 years (not in patients younger than 50 years or older than 65 years). In conclusion, increasing serum 25(OH)D concentrations may be potentially helpful for the treatment of hyperlipidemia in people with vitamin D deficiency.
维生素D缺乏与高脂血症有关，但补充维生素D是否能降低血脂水平尚不清楚。本研究的目的是调查血清25-羟基维生素D（25(OH)D）浓度升高与血脂水平之间的关联，并确定25(OH)D水平升高伴或不伴有血脂降低人群的特征。对118例个体（53名男性；平均年龄54.4±10.6岁）的病历进行回顾性分析，这些个体在连续两次测量中血清25(OH)D水平升高。25(OH)D水平升高的人群（从22.7（17.6 - 29.2）mg/dL升至32.1（25.6 - 36.8）mg/dL；P < 0.01）血清甘油三酯（TGs）水平显著降低（从111.0（80 - 164）mg/dL降至104.5（73 - 142）mg/dL；P < 0.01），总胆固醇（TC）水平也显著降低（从187.5（155 - 213）mg/dL降至181.0（150 - 210）mg/dL；P < 0.05）。对维生素D有反应（TG或TC水平降低≥10%）的个体，其基线TG和TC水平显著高于无反应者。仅基线时患有高脂血症的患者（而非无高脂血症者）在随访时TG和TC水平显著降低。然而，血清25(OH)D浓度升高与基线25(OH)D水平低于30 ng/mL的个体以及50 - 65岁个体（而非年龄小于50岁或大于65岁的患者）的血脂水平降低显著相关。总之，血清25(OH)D浓度升高可能对维生素D缺乏人群的高脂血症治疗有潜在帮助。
