酶动力学中的进展曲线分析。积分速率方程的数值解。
Progress-curve analysis in enzyme kinetics. Numerical solution of integrated rate equations.
作者信息
Duggleby R G
出版信息
Biochem J. 1986 Apr 15;235(2):613-5. doi: 10.1042/bj2350613.
Abstract
Progress curves of enzyme-catalysed reactions are described by equations of a type that precludes direct calculation of the extent of reaction at any time. Previously, such equations have been solved by the Newton-Raphson method, but this procedure may fail when based upon the usual formulae. An alternative formulation is proposed that is both quicker and more robust.
摘要
酶催化反应的进程曲线由一类方程描述，这类方程排除了在任何时刻直接计算反应程度的可能性。以前，此类方程是通过牛顿 - 拉夫逊方法求解的，但基于常规公式时该方法可能会失败。本文提出了一种更快且更稳健的替代公式。
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本文引用的文献
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Analysis of progress curves for a highly concentrated Michaelian enzyme in the presence or absence of product inhibition.在存在或不存在产物抑制的情况下，对高浓度米氏酶的进程曲线进行分析。
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Integrated steady state rate equations and the determination of individual rate constants.综合稳态速率方程与单个速率常数的测定
J Biol Chem. 1975 Jun 25;250(12):4696-701.
4
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