Institute of Medical Biochemistry Leopoldo de Meis, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.
J Neurochem. 2023 Jul;166(1):3-6. doi: 10.1111/jnc.15879.
This preface introduces the Journal of Neurochemistry Special Issue on Brain Proteostasis. Adequate control of protein homeostasis, or proteostasis, has been at the center stage of brain physiology, and its deregulation may contribute to brain diseases, including several neuropsychiatric and neurodegenerative conditions. Therefore, delineating the processes underlying protein synthesis, folding, stability, function, and degradation in brain cells is key to promoting brain function and identifying effective therapeutic options for neurological disorders. This special issue comprises four review articles and four original articles covering the roles of protein homeostasis in several mechanisms that are of relevance to sleep, depression, stroke, dementia, and COVID-19. Thus, these articles highlight different aspects of proteostasis regulation in the brain and present important evidence on this growing and exciting field.
这篇序言介绍了《神经化学杂志》关于大脑蛋白质稳态的特刊。蛋白质稳态的充分控制，或者说蛋白质体稳态，一直是大脑生理学的核心，其失调可能导致包括几种神经精神和神经退行性疾病在内的脑部疾病。因此，阐明脑细胞中蛋白质合成、折叠、稳定性、功能和降解的过程是促进大脑功能和确定治疗神经紊乱的有效治疗方案的关键。本特刊包括四篇综述文章和四篇原始文章，涵盖了蛋白质体稳态在与睡眠、抑郁、中风、痴呆和 COVID-19 相关的几种机制中的作用。因此，这些文章强调了大脑中蛋白质体稳态调节的不同方面，并提供了该不断发展和令人兴奋的领域的重要证据。
