Department of Clinical Biochemistry, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, Iran.
Nutrition and Food Security Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
Cell Mol Neurobiol. 2023 Oct;43(7):3277-3299. doi: 10.1007/s10571-023-01385-x. Epub 2023 Jul 6.
MicroRNAs (miRNAs) are non-coding RNAs with only 20-22 nucleic acids that inhibit gene transcription and translation by binding to mRNA. MiRNAs have a diverse set of target genes and can alter most physiological processes, including cell cycle checkpoints, cell survival, and cell death mechanisms, affecting the growth, development, and invasion of various cancers, including gliomas. So optimum management of miRNA expression is essential for preserving a normal biological environment. Due to their small size, stability, and capability of specifically targeting oncogenes, miRNAs have emerged as a promising marker and new biopharmaceutical targeted therapy for glioma patients. This review focuses on the most common miRNAs associated with gliomagenesis and development by controlling glioma-determining markers such as angiogenesis. We also summarized the recent research about miRNA effects on signaling pathways, their mechanistic role and cellular targets in the development of gliomas angiogenesis. Strategies for miRNA-based therapeutic targets, as well as limitations in clinical applications, are also discussed.
MicroRNAs (miRNAs) 是仅由 20-22 个核苷酸组成的非编码 RNA，通过与 mRNA 结合来抑制基因转录和翻译。miRNAs 具有多样化的靶基因，可以改变大多数生理过程，包括细胞周期检查点、细胞存活和细胞死亡机制，从而影响各种癌症的生长、发育和侵袭，包括神经胶质瘤。因此，最佳的 miRNA 表达调控对于维持正常的生物环境至关重要。由于 miRNA 体积小、稳定性好、能够特异性靶向癌基因，因此作为神经胶质瘤患者的有前途的标志物和新型生物制药靶向治疗药物而备受关注。本综述重点关注通过控制血管生成等神经胶质瘤决定标志物与神经胶质瘤发生和发展相关的最常见 miRNAs。我们还总结了 miRNA 对信号通路的影响及其在神经胶质瘤血管生成发展中的作用机制和细胞靶点的最新研究。还讨论了 miRNA 为基础的治疗靶点的策略以及临床应用中的限制。
