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美国成年人糖尿病与乳腺癌的关联：来自美国国家健康与营养调查的结果。

Association between diabetes status and breast cancer in US adults: findings from the US National Health and Nutrition Examination Survey.

机构信息

Department of General Surgery, The Second Xiangya Hospital, Central South University, Changsha, China.

Department of Gynecology, The Affiliated Traditional Chinese Medicine Hospital of Southwest Medical University, Luzhou, Sichuan, China.

出版信息

Front Endocrinol (Lausanne). 2023 Jun 21;14:1059303. doi: 10.3389/fendo.2023.1059303. eCollection 2023.

DOI:10.3389/fendo.2023.1059303
PMID:37415670
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10321597/
Abstract

OBJECTIVES

The aim of this study was to investigate the association between diabetes status and the risk of breast cancer among adult Americans, exploring the impact of BMI, age, and race on this relationship.

METHODS

A cross-sectional analysis of 8,249 individuals from the National Health and Nutrition Examination Survey (NHANES) was conducted. Diabetes was categorized as type 2 diabetes and prediabetes, with both conditions diagnosed according to the ADA 2014 guidelines. The association between diabetes status and breast cancer risk was explored using multiple logistic regression analysis.

RESULTS

Patients with diabetes had higher odds of breast cancer (OR: 1.51; 95% CI 1.00 to 2.28), Using the two-piecewise linear regression model, it was observed that there is a threshold effect in the risk of breast cancer occurrence at the age of 52 years. Specifically, the risk of breast cancer is relatively low before the age of 52 but increases significantly after this age.

CONCLUSIONS

This study identified a significant association between diabetes status and breast cancer risk among adult Americans. We also found a threshold effect in breast cancer occurrence at the age of 52. Age was significantly associated with breast cancer risk in both Non-Hispanic White and Non-Hispanic Black individuals. These findings underscore the importance of diabetes management, maintaining a healthy BMI, and age-related risk considerations in reducing breast cancer risk.

摘要

目的

本研究旨在探讨美国成年人中糖尿病状况与乳腺癌风险之间的关系，探讨 BMI、年龄和种族对这种关系的影响。

方法

对来自国家健康和营养检查调查（NHANES）的 8249 名个体进行了横断面分析。糖尿病分为 2 型糖尿病和糖尿病前期，根据 ADA 2014 指南诊断这两种情况。使用多因素逻辑回归分析探讨糖尿病状况与乳腺癌风险之间的关系。

结果

患有糖尿病的患者患乳腺癌的几率更高（OR：1.51；95%CI 1.00 至 2.28）。使用两段线性回归模型，观察到 52 岁时乳腺癌发生风险存在阈值效应。具体而言，52 岁之前乳腺癌的风险相对较低，但在此年龄之后显著增加。

结论

本研究确定了美国成年人中糖尿病状况与乳腺癌风险之间存在显著关联。我们还发现 52 岁时乳腺癌发生存在阈值效应。年龄在非西班牙裔白人和非西班牙裔黑人个体中均与乳腺癌风险显著相关。这些发现强调了糖尿病管理、保持健康的 BMI 和与年龄相关的风险考虑在降低乳腺癌风险中的重要性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e981/10321597/2b2a13c92567/fendo-14-1059303-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e981/10321597/70a4a58e040f/fendo-14-1059303-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e981/10321597/921d97cee950/fendo-14-1059303-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e981/10321597/a4578de43d64/fendo-14-1059303-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e981/10321597/a3e2b65c447c/fendo-14-1059303-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e981/10321597/2b2a13c92567/fendo-14-1059303-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e981/10321597/70a4a58e040f/fendo-14-1059303-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e981/10321597/921d97cee950/fendo-14-1059303-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e981/10321597/a4578de43d64/fendo-14-1059303-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e981/10321597/a3e2b65c447c/fendo-14-1059303-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e981/10321597/2b2a13c92567/fendo-14-1059303-g005.jpg

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