对家犬作为一例由……引起的人类菌血症病例来源的调查。 （原文此处不完整，有缺失内容）
An investigation of household dogs as the source in a case of human bacteraemia caused by .
作者信息
Östholm Balkhed Åse, Söderlund Robert, Gunnarsson Lotta, Wikström Camilla, Ljung Helena, Claesson Carina, Börjesson Stefan
机构信息
Department of Biomedical and Clinical Sciences, Linköping University, Linköping, Sweden.
Department of Microbiology, National Veterinary Institute, Uppsala, Sweden.
出版信息
Infect Ecol Epidemiol. 2023 Jul 3;13(1):2229578. doi: 10.1080/20008686.2023.2229578. eCollection 2023.
is a commensal and an opportunistic pathogen in dogs, and is also an opportunistic pathogen in humans. Here we report about a case of bacteraemia with a fatal outcome in a 77-year-old co-morbid male likely caused by a and the investigation into the possible transmission from the two dogs in the patient's household. The two dogs carried the same strain, but this dog strain was unrelated to the strain from the patient. In contrast to the patient strain, the dog strain showed reduced susceptibility to several antibiotics and both dogs had received antibiotic treatment prior to sampling. So, it is conceivable that these treatments can have eliminated the patient's strain between the transmission event and the dog sampling. It is also worth noting that the patient strain was positive for the A gene, which encodes an exfoliative toxin closely related to the exfoliative toxin B. This toxin has been linked to canine pyoderma, but its effect on humans remains unknown. Transmission of was confirmed in the household between the dogs. However, we could not verify that the dogs were the source for the in the patient.
在犬类中是共生菌和机会致病菌，在人类中也是机会致病菌。在此我们报告一例77岁患有多种疾病的男性患者发生菌血症并导致死亡的病例，可能由一种[细菌名称未给出]引起，同时对患者家中两只狗可能的传播情况进行了调查。这两只狗携带相同的[细菌名称未给出]菌株，但该犬类菌株与患者的菌株无关。与患者菌株相比，犬类菌株对几种抗生素的敏感性降低，且两只狗在采样前均接受过抗生素治疗。所以，可以想象这些治疗可能在传播事件和犬类采样之间消除了患者的菌株。还值得注意的是，患者菌株的A基因呈阳性，该基因编码一种与[细菌名称未给出]剥脱毒素B密切相关的剥脱毒素。这种毒素与犬类脓皮病有关，但其对人类的影响尚不清楚。已证实[细菌名称未给出]在该家庭的狗之间传播。然而，我们无法证实狗是患者体内[细菌名称未给出]的来源。
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