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一名接触家养宠物的肺移植受者发生中间型假葡萄球菌菌血症。

Staphylococcus pseudintermedius Bacteremia in a Lung Transplant Recipient Exposed to Domestic Pets.

作者信息

Small Coulter, Beatty Norman, El Helou Guy

机构信息

Division of Infectious Diseases and Global Medicine, Department of Medicine, University of Florida College of Medicine, Gainesville, USA.

出版信息

Cureus. 2021 May 7;13(5):e14895. doi: 10.7759/cureus.14895.

Abstract

commonly colonizes companion animals, including canines. This microbe is a major opportunistic pathogen responsible for pyogenic and necrotizing skin and soft tissue infection in canines. Infection with is increasingly being recognized in humans, especially in those who are immunocompromised This microbe is quite similar to , expressing several analogous virulence factors and a variety of toxins. Furthermore, has variants that display multi-drug resistance comparable to methicillin-resistant . We report a 50-year-old female with bilateral lung transplant on immunosuppression who presents with signs of sepsis and pneumonia. Initial blood cultures grew Gram-positive cocci that were not initially identified via molecular diagnostics as species but were later confirmed as through mass spectrometry. Antimicrobial susceptibility testing demonstrated multi-drug resistance, including methicillin. Despite aggressive medical and antimicrobial treatment, our patients succumbed to the infection. The source of infection likely came from her companion canine at home as no other source could be identified; however, cultures were unable to be obtained from the companion canine. Those who are immunosuppressed, such as with solid organ transplants, should take caution with exposure to companion animals due to the potential for infection.

摘要

通常定植于伴侣动物,包括犬类。这种微生物是引起犬类化脓性和坏死性皮肤及软组织感染的主要机会性病原体。人类,尤其是免疫功能低下者,感染这种微生物的情况越来越受到关注。这种微生物与[另一种微生物名称]非常相似,表达几种类似的毒力因子和多种毒素。此外,[这种微生物名称]有一些变体,其表现出的多重耐药性与耐甲氧西林[另一种微生物名称]相当。我们报告了一名50岁接受双侧肺移植并接受免疫抑制治疗的女性,她出现了败血症和肺炎的症状。最初的血培养生长出革兰氏阳性球菌,最初通过分子诊断未鉴定为[这种微生物名称],但后来通过质谱法确认为[这种微生物名称]。药敏试验显示其具有多重耐药性,包括对甲氧西林耐药。尽管进行了积极的药物和抗菌治疗,我们的患者仍死于感染。感染源可能来自她家中的伴侣犬,因为未发现其他来源;然而,未能从伴侣犬身上获取培养物。免疫功能低下者,如接受实体器官移植者,由于有感染[这种微生物名称]的潜在风险,接触伴侣动物时应谨慎。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3613/8180354/32b4aaa90496/cureus-0013-00000014895-i01.jpg

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