1 Área Bioquímica y Biología Molecular, Universidad de La Rioja , Logroño, Spain .
2 Área Microbiología Molecular, Centro de Investigación Biomédica de la Rioja , Logroño, Spain .
Vector Borne Zoonotic Dis. 2017 Apr;17(4):268-270. doi: 10.1089/vbz.2016.2048. Epub 2017 Jan 11.
Staphylococcus pseudintermedius is an opportunistic pathogen that has been identified as infectious agent or colonizer mainly in dogs. S. pseudintermedius has been also detected in humans and more specifically in people in contact with dogs. In this study, the possible S. pseudintermedius pet-to-human transmission was analyzed in four clinical human cases. Two patients were dog owners and S. pseudintermedius was also detected as colonizer in these healthy animals. S. pseudintermedius isolates from patients and dogs of the same household showed identical pulsed-field gel electrophoresis patterns, sequence types (STs), and antimicrobial resistance phenotypes and genotypes, and were methicillin susceptible. Resistance to erythromycin, clindamycin, tetracycline, trimetoprim-sulfamethoxazole, and/or ciprofloxacin was identified among S. pseudintermedius strains. The lineages ST241 and the new ST521 were detected in the strains of the two dog-owner patients, respectively. The strains from the other two patients presented two new STs, ST719 and ST720. To our knowledge, this is the first description of human infections caused by S. pseudintermedius in Spain.
中间葡萄球菌是一种机会致病菌，主要被认为是狗的感染源或定植菌。中间葡萄球菌也已在人类中被检测到，尤其是在与狗接触的人群中。在这项研究中，分析了 4 例临床人类病例中中间葡萄球菌从宠物到人类的可能传播情况。2 名患者是狗主人，这些健康动物也被检测为中间葡萄球菌定植菌。来自同一家庭的患者和狗的中间葡萄球菌分离株显示出相同的脉冲场凝胶电泳图谱、序列型（ST）和抗生素耐药表型和基因型，且对甲氧西林敏感。中间葡萄球菌菌株中存在对红霉素、克林霉素、四环素、复方磺胺甲噁唑和/或环丙沙星的耐药性。在两名狗主人患者的菌株中分别检测到 ST241 和新的 ST521 谱系。来自另外两名患者的菌株呈现出两种新的 ST，ST719 和 ST720。据我们所知，这是首次在西班牙描述由中间葡萄球菌引起的人类感染。
