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新冠感染与糖尿病酮症酸中毒共存的管理难点（病例报告；两例新诊断糖尿病患儿）。

Management Difficulties in the Coexistence of Covid-19 Infection and Diabetic Ketoacidosis (Case Report; Two Children with Newly Diagnosed Diabetes).

机构信息

Division of Pediatric Endocrinology, Gaziantep Children's Hospital, Gaziantep, Turkey.

Division of Pediatric Infection Diasese, Gaziantep Children's Hospital, Gaziantep, Turkey.

出版信息

Ann Afr Med. 2023 Jul-Sep;22(3):388-391. doi: 10.4103/aam.aam_250_21.

DOI:10.4103/aam.aam_250_21
PMID:37417031
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10445706/
Abstract

Two 8-year-old girls were admitted to the emergency department with diabetic ketoacidosis (DKA) approximately 10 days apart. The patients with resistant severe acidosis and high infection parameters were diagnosed with COVID-19 by real-time reverse transcription-polymerase chain reaction test. Accompanying pneumonia was observed in one of the patients. Here, we aimed to discuss the difficulties in the management of patients with a new diagnosis of DKA with COVID-19 infection. In addition, we wanted to emphasize that COVID-19 infection may be effective in the development of diabetes in patients with a genetic predisposition.

摘要

两名 8 岁女孩大约相隔 10 天因糖尿病酮症酸中毒（DKA）被收入急诊科。两名患者均存在严重酸中毒且感染参数较高，通过实时逆转录聚合酶链反应检测诊断为 COVID-19 感染。其中一名患者伴有肺炎。在这里，我们旨在讨论管理新发 DKA 合并 COVID-19 感染患者时的困难。此外，我们想强调 COVID-19 感染可能在遗传易感性患者中导致糖尿病的发生。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2662/10445706/d23827a2d59d/AAM-22-388-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2662/10445706/1ba8a4950196/AAM-22-388-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2662/10445706/359365a307c9/AAM-22-388-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2662/10445706/d23827a2d59d/AAM-22-388-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2662/10445706/1ba8a4950196/AAM-22-388-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2662/10445706/359365a307c9/AAM-22-388-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2662/10445706/d23827a2d59d/AAM-22-388-g003.jpg

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本文引用的文献

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New onset diabetes, type 1 diabetes and COVID-19.新发糖尿病、1 型糖尿病与 COVID-19。
Diabetes Metab Syndr. 2020 Nov-Dec;14(6):2211-2217. doi: 10.1016/j.dsx.2020.11.012. Epub 2020 Nov 17.
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Diabetic ketoacidosis precipitated by COVID-19: A report of two cases and review of literature.由新型冠状病毒肺炎引发的糖尿病酮症酸中毒：两例报告及文献综述
Diabetes Metab Syndr. 2020 Sep-Oct;14(5):1459-1462. doi: 10.1016/j.dsx.2020.07.050. Epub 2020 Aug 1.
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COVID-19 infection may cause ketosis and ketoacidosis.COVID-19 感染可能导致酮症和酮酸中毒。
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Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study.中国武汉成人 COVID-19 住院患者的临床病程和死亡危险因素：一项回顾性队列研究。
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Clinical Characteristics of 138 Hospitalized Patients With 2019 Novel Coronavirus-Infected Pneumonia in Wuhan, China.《武汉 2019 年新型冠状病毒感染的肺炎 138 例住院患者临床特征分析》
JAMA. 2020 Mar 17;323(11):1061-1069. doi: 10.1001/jama.2020.1585.
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ISPAD Clinical Practice Consensus Guidelines 2018: Diabetic ketoacidosis and the hyperglycemic hyperosmolar state.《国际儿童和青少年糖尿病学会（ISPAD）2018年临床实践共识指南：糖尿病酮症酸中毒和高血糖高渗状态》
Pediatr Diabetes. 2018 Oct;19 Suppl 27:155-177. doi: 10.1111/pedi.12701.
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Respiratory infections are temporally associated with initiation of type 1 diabetes autoimmunity: the TEDDY study.呼吸道感染与 1 型糖尿病自身免疫的起始呈时间相关性：TEDDY 研究。
Diabetologia. 2017 Oct;60(10):1931-1940. doi: 10.1007/s00125-017-4365-5. Epub 2017 Aug 2.
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