Chaubey Trayambek Nath, Borpatra Paran J, Pandey Satyendra Kumar
Department of Chemistry, Institute of Science, Banaras Hindu University, Varanasi 221005, India.
Org Lett. 2023 Jul 21;25(28):5329-5332. doi: 10.1021/acs.orglett.3c01907. Epub 2023 Jul 7.
A novel straightforward and catalyst-free approach for synthesizing quinoxaline derivatives from sulfoxonium ylides and -phenylenediamines mediated by elemental sulfur has been described. Due to the simple and mild reaction conditions, the sulfoxonium ylides and -phenylenediamines decorated with different functional groups furnished moderate to high yields of quinoxaline derivatives and were well tolerated. Finally, large-scale reactions, the synthesis of pyrazines, and some bioactive compounds are used to illustrate the potential utility of the developed approach.
描述了一种由元素硫介导的、新颖的、直接且无催化剂的方法，用于从氧化锍叶立德和对苯二胺合成喹喔啉衍生物。由于反应条件简单温和，带有不同官能团的氧化锍叶立德和对苯二胺能以中等至高产率得到喹喔啉衍生物，且耐受性良好。最后，通过大规模反应、吡嗪的合成以及一些生物活性化合物来说明所开发方法的潜在实用性。
