通过元素硫介导的实用方法获得杂合喹喔啉支架，实现向π-扩展和氮杂环化杂环单元的转化。
Pragmatic Access to Hybrid Quinoxaline Scaffold Mediated by Elemental Sulfur Enabling Actualization to π-Extended and Aza-Annulated Heterocyclic Units.
作者信息
Ghosh Swarnali, Das Dwaipayan, Mandal Rahul Dev, Das Asish R
机构信息
Department of Chemistry, University of Calcutta, 92, A. P. C. Road, Kolkata 700009, India.
出版信息
J Org Chem. 2024 Oct 18;89(20):15358-15363. doi: 10.1021/acs.joc.4c01972. Epub 2024 Sep 27.
A metal-free approach for synthesizing hybrid quinoxaline derivatives from sulfoxonium ylide and a 1,5-bis-nucleophilic N-heterocycle mediated by elemental sulfur is presented to illuminate the [5+1] cascade cyclization sequence. Large-scale synthesis and postsynthetic functionalizations for the annulative π-extension and intramolecular aza-annulation reactions reveal the potential utility and actualize the fabricated approach.
本文提出了一种无金属方法，用于由硫叶立德和由元素硫介导的1,5-双亲核N-杂环合成杂化喹喔啉衍生物，以阐明[5+1]级联环化序列。用于累积π-扩展和分子内氮杂环化反应的大规模合成和合成后官能化揭示了其潜在用途，并实现了所构建的方法。
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