Shanxi Key Laboratory of Otorhinolaryngology Head and Neck Cancer, First Hospital of Shanxi Medical University, Taiyuan 030001, Shanxi, PR China; Department of Anatomy, the Basic Medical School of Shanxi Medical University, Taiyuan 030001, Shanxi, PR China.
Shanxi Key Laboratory of Otorhinolaryngology Head and Neck Cancer, First Hospital of Shanxi Medical University, Taiyuan 030001, Shanxi, PR China; Department of Cell biology and Genetics, the Basic Medical School of Shanxi Medical University, Taiyuan 030001, Shanxi, PR China.
Biomed Pharmacother. 2023 Sep;165:115115. doi: 10.1016/j.biopha.2023.115115. Epub 2023 Jul 5.
MicroRNAs (miRNAs) are a class of small non-coding RNAs that post-transcriptionally regulate the expression of approximately 50 % of all protein-coding genes. They have been demonstrated to act as key regulators in various pathophysiological processes and play significant roles in a wide range of human diseases, particularly cancer. Current research highlights the aberrant expression of microRNA-488 (miR-488) in multiple human diseases and its critical involvement in disease initiation and progression. Moreover, the expression level of miR-488 has been linked to clinicopathological features and patient prognosis across different diseases. However, a comprehensive systematic review of miR-488 is lacking. Therefore, our study aims to consolidate the current knowledge surrounding miR-488, with a primary focus on its emerging biological functions, regulatory mechanisms, and potential clinical applications in human diseases. Through this review, we aim to establish a comprehensive understanding of the diverse roles of miR-488 in the development of various diseases.
微小 RNA（miRNA）是一类小的非编码 RNA，它们在后转录水平上调节大约 50%的全部蛋白编码基因的表达。已经证明它们在各种病理生理过程中作为关键调节剂发挥作用，并在广泛的人类疾病中发挥重要作用，特别是癌症。目前的研究强调了 miRNA-488（miR-488）在多种人类疾病中的异常表达及其在疾病起始和进展中的关键作用。此外，miR-488 的表达水平与不同疾病的临床病理特征和患者预后相关。然而，miR-488 的全面系统综述仍然缺乏。因此，我们的研究旨在整合当前围绕 miR-488 的知识，主要关注其新兴的生物学功能、调控机制以及在人类疾病中的潜在临床应用。通过本次综述，我们旨在全面了解 miR-488 在各种疾病发展中的多种作用。
