蛋蛋白水解物NWT-03对代谢综合征成年人动脉僵硬度和心脏代谢风险标志物的长期影响：一项随机、双盲、安慰剂对照、交叉试验。
Longer-term effects of the egg-protein hydrolysate NWT-03 on arterial stiffness and cardiometabolic risk markers in adults with metabolic syndrome: a randomized, double-blind, placebo-controlled, crossover trial.
作者信息
Nijssen Kevin M R, Joris Peter J, Mensink Ronald P, Plat Jogchum
机构信息
Department of Nutrition and Movement Sciences, NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University, Maastricht, The Netherlands.
出版信息
Eur J Clin Nutr. 2023 Oct;77(10):982-988. doi: 10.1038/s41430-023-01305-8. Epub 2023 Jul 7.
BACKGROUND
Short-term intake of egg-derived protein hydrolysates, such as NWT-03, suggest improvements in arterial stiffness and metabolic profiles, but longer-term trials are lacking. This study therefore examined the longer-term effects of NWT-03 on arterial stiffness and cardiometabolic markers in men and women with metabolic syndrome.
METHODS
Seventy-six adults with metabolic syndrome (age 61 ± 10 years; BMI 31.7 ± 4.0 kg/m) participated in a randomized, controlled, double-blind, cross-over trial with a 27-day intervention (5 g/day NWT-03) or placebo period, separated by two-to-eight weeks of washout. At the start and end of both periods, measurements were performed in the fasting state and 2 h following acute NWT-03 intake. Arterial stiffness was assessed by carotid-to-radial (PWV), carotid-to-femoral pulse wave velocity (PWV), and central augmentation index (CAIxHR75). Moreover, cardiometabolic markers were assessed.
RESULTS
Compared with control, longer-term NWT-03 supplementation did not affect fasting PWV (0.1 m/s; -0.2 to 0.3; P = 0.715) or PWV (-0.2 m/s; -0.5 to 0.1; P = 0.216). Fasting pulse pressure (PP) was however reduced by 2 mmHg (95% CI: -4 to 0; P = 0.043), but other fasting cardiometabolic markers were not affected. No effects were observed following acute NWT-03 intake at baseline. However, acute intake of NWT-03 after the intervention significantly lowered CAIxHR75 (-1.3%-point; -2.6 to -0.1; P = 0.037) and diastolic BP (-2 mmHg; -3 to 0; P = 0.036), but other cardiometabolic markers did not change.
CONCLUSION
Longer-term NWT-03 supplementation did not affect arterial stiffness, but modestly improved fasting PP in adults with metabolic syndrome. Acute intake of NWT-03 after the intervention also improved CAIxHR75 and diastolic BP.
TRIAL REGISTRATION
The study was registered at ClinicalTrials.gov as NCT02561663.
背景
短期摄入鸡蛋来源的蛋白水解物，如NWT-03，显示动脉僵硬度和代谢指标有所改善，但缺乏长期试验。因此，本研究探讨了NWT-03对代谢综合征男性和女性动脉僵硬度和心脏代谢标志物的长期影响。
方法
76名患有代谢综合征的成年人（年龄61±10岁；体重指数31.7±4.0kg/m）参与了一项随机、对照、双盲、交叉试验，进行为期27天的干预（每天5g NWT-03）或安慰剂期，中间间隔2至8周的洗脱期。在两个阶段的开始和结束时，在空腹状态下以及急性摄入NWT-03后2小时进行测量。通过颈-桡脉搏波速度（PWV）、颈-股脉搏波速度（PWV）和中心增强指数（CAIxHR75）评估动脉僵硬度。此外，还评估了心脏代谢标志物。
结果
与对照组相比，长期补充NWT-03对空腹PWV（0.1m/s；-0.2至0.3；P=0.715）或PWV（-0.2m/s；-0.5至0.1；P=0.216）无影响。然而，空腹脉压（PP）降低了2mmHg（95%CI：-4至0；P=0.043），但其他空腹心脏代谢标志物未受影响。在基线时急性摄入NWT-03后未观察到影响。然而，干预后急性摄入NWT-03显著降低了CAIxHR75（-1.3个百分点；-2.6至-0.1；P=0.037）和舒张压（-2mmHg；-3至0；P=0.036），但其他心脏代谢标志物未改变。
结论
长期补充NWT-03对动脉僵硬度无影响，但适度改善了代谢综合征成年人的空腹PP。干预后急性摄入NWT-03也改善了CAIxHR75和舒张压。
试验注册
该研究在ClinicalTrials.gov上注册为NCT02561663。
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