Nijssen Kevin M R, Joris Peter J, Mensink Ronald P, Plat Jogchum
Department of Nutrition and Movement Sciences, NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University, Maastricht, The Netherlands.
Eur J Clin Nutr. 2023 Oct;77(10):982-988. doi: 10.1038/s41430-023-01305-8. Epub 2023 Jul 7.
Short-term intake of egg-derived protein hydrolysates, such as NWT-03, suggest improvements in arterial stiffness and metabolic profiles, but longer-term trials are lacking. This study therefore examined the longer-term effects of NWT-03 on arterial stiffness and cardiometabolic markers in men and women with metabolic syndrome.
Seventy-six adults with metabolic syndrome (age 61 ± 10 years; BMI 31.7 ± 4.0 kg/m) participated in a randomized, controlled, double-blind, cross-over trial with a 27-day intervention (5 g/day NWT-03) or placebo period, separated by two-to-eight weeks of washout. At the start and end of both periods, measurements were performed in the fasting state and 2 h following acute NWT-03 intake. Arterial stiffness was assessed by carotid-to-radial (PWV), carotid-to-femoral pulse wave velocity (PWV), and central augmentation index (CAIxHR75). Moreover, cardiometabolic markers were assessed.
Compared with control, longer-term NWT-03 supplementation did not affect fasting PWV (0.1 m/s; -0.2 to 0.3; P = 0.715) or PWV (-0.2 m/s; -0.5 to 0.1; P = 0.216). Fasting pulse pressure (PP) was however reduced by 2 mmHg (95% CI: -4 to 0; P = 0.043), but other fasting cardiometabolic markers were not affected. No effects were observed following acute NWT-03 intake at baseline. However, acute intake of NWT-03 after the intervention significantly lowered CAIxHR75 (-1.3%-point; -2.6 to -0.1; P = 0.037) and diastolic BP (-2 mmHg; -3 to 0; P = 0.036), but other cardiometabolic markers did not change.
Longer-term NWT-03 supplementation did not affect arterial stiffness, but modestly improved fasting PP in adults with metabolic syndrome. Acute intake of NWT-03 after the intervention also improved CAIxHR75 and diastolic BP.
The study was registered at ClinicalTrials.gov as NCT02561663.
短期摄入鸡蛋来源的蛋白水解物，如NWT-03，显示动脉僵硬度和代谢指标有所改善，但缺乏长期试验。因此，本研究探讨了NWT-03对代谢综合征男性和女性动脉僵硬度和心脏代谢标志物的长期影响。
76名患有代谢综合征的成年人（年龄61±10岁；体重指数31.7±4.0kg/m）参与了一项随机、对照、双盲、交叉试验，进行为期27天的干预（每天5g NWT-03）或安慰剂期，中间间隔2至8周的洗脱期。在两个阶段的开始和结束时，在空腹状态下以及急性摄入NWT-03后2小时进行测量。通过颈-桡脉搏波速度（PWV）、颈-股脉搏波速度（PWV）和中心增强指数（CAIxHR75）评估动脉僵硬度。此外，还评估了心脏代谢标志物。
与对照组相比，长期补充NWT-03对空腹PWV（0.1m/s；-0.2至0.3；P=0.715）或PWV（-0.2m/s；-0.5至0.1；P=0.216）无影响。然而，空腹脉压（PP）降低了2mmHg（95%CI：-4至0；P=0.043），但其他空腹心脏代谢标志物未受影响。在基线时急性摄入NWT-03后未观察到影响。然而，干预后急性摄入NWT-03显著降低了CAIxHR75（-1.3个百分点；-2.6至-0.1；P=0.037）和舒张压（-2mmHg；-3至0；P=0.036），但其他心脏代谢标志物未改变。
长期补充NWT-03对动脉僵硬度无影响，但适度改善了代谢综合征成年人的空腹PP。干预后急性摄入NWT-03也改善了CAIxHR75和舒张压。
该研究在ClinicalTrials.gov上注册为NCT02561663。
