Instituto de Investigação, Inovação e Desenvolvimento da Universidade Fernando Pessoa (FP-I3ID), Gondomar, Porto, Portugal.
Hospital-Escola da Universidade Fernando Pessoa (HE-UFP), Gondomar, Porto, Portugal.
Int Ophthalmol. 2023 Oct;43(10):3777-3784. doi: 10.1007/s10792-023-02788-x. Epub 2023 Jul 7.
To compare 0.01% atropine with DIMS spectacle lenses in the prevention of myopia progression in European children.
This was a retrospective study including data from pediatric European patients with myopia. From November 2021 to March 2022, only 0.01% atropine was prescribed because DIMS lenses were still not available in Portugal. From March to October 2022, only DIMS spectacle lenses were prescribed due to patients' parents' preference. Myopia progression endpoints were axial length (AL) and spherical equivalent (SE) differences between before and 6 months after treatment. AL and SE evolution were compared using a general linear model with repeated measures.
The study included 98 eyes from 50 patients: 47 in the atropine group and 51 in the DIMS group. There were no statistically significant differences between groups in terms of initial AL, initial SE, sex or age. The mean AL elongation at 6 months was 0.057 mm in the atropine group (SD = 0.118) and 0.002 mm (SD = 0.077) in the DIMS group. SE progression was - 0.098 (SD = 0.232) D in the atropine group and - 0.039 (SD = 0.105) D in the DIMS group. AL elongation was significantly lower in the DIMS lens group (p = 0.038, partial Eta = 0.045). There was no difference in SE progression between groups (p = 0.302, partial Eta = 0.011).
Comparison between 0.01% atropine eyedrops and DIMS spectacle lenses for slowing the progression of myopia favored DIMS lenses in terms of AL elongation in a short-term follow-up. There was no difference in terms of SE between groups.
比较 0.01%阿托品与 DIMS 离焦镜在预防欧洲儿童近视进展中的效果。
这是一项回顾性研究，纳入了欧洲近视患儿的儿科数据。2021 年 11 月至 2022 年 3 月，由于葡萄牙尚未引进 DIMS 镜片，仅开 0.01%阿托品。2022 年 3 月至 10 月，由于患者家长的偏好，仅开 DIMS 离焦镜。近视进展的终点是治疗前后 6 个月时眼轴（AL）和等效球镜（SE）的差异。采用重复测量的一般线性模型比较 AL 和 SE 的演变。
本研究纳入了 50 例患者的 98 只眼：阿托品组 47 只，DIMS 组 51 只。两组在初始 AL、初始 SE、性别或年龄方面无统计学差异。阿托品组 6 个月时 AL 伸长 0.057mm（SD=0.118），DIMS 组伸长 0.002mm（SD=0.077）。阿托品组 SE 进展-0.098（SD=0.232）D，DIMS 组-0.039（SD=0.105）D。DIMS 镜片组的 AL 伸长明显较低（p=0.038，部分 Eta=0.045）。两组 SE 进展无差异（p=0.302，部分 Eta=0.011）。
0.01%阿托品滴眼液与 DIMS 离焦镜在减缓近视进展方面的比较，在短期随访中，DIMS 镜片在 AL 伸长方面更有优势。两组间 SE 无差异。
