Centre for Myopia Research, School of Optometry, The Hong Kong Polytechnic University, Kowloon, Hong Kong
Centre for Eye and Vision Research (CEVR), Hong Kong, Hong Kong.
Br J Ophthalmol. 2022 Aug;106(8):1110-1114. doi: 10.1136/bjophthalmol-2020-317664. Epub 2021 Mar 17.
To determine myopia progression in children who continued to wear the defocus incorporated multiple segments (DIMS) lenses or switched from single vision (SV) to DIMS lenses for a 1-year period following a 2-year myopia control trial.
128 children participated in this study. The children who had worn DIMS lenses continued to wear DIMS lenses (DIMS group), and children who had worn SV lenses switched to wear DIMS lenses (Control-to-DIMS group). Cycloplegic spherical equivalent refraction (SER) and axial length (AL) were measured at 6-month interval. Historical controls were age matched to the DIMS group at 24 months and used for comparing the third-year changes.
Over 3 years, SER and AL changes in the DIMS group (n=65) were -0.52±0.69D and 0.31±0.26 mm; these changes were not statistically significant over time (repeated measures analysis of variance, p>0.05).SER (-0.04±0. 38D) and AL (0.08±0.12 mm) changes in the Control-to-DIMS group (n=55) in the third year were less compared with the first (mean difference=0.45 ± 0.30D, 0.21±0.11 mm, p<0.001) and second (0.34±0.30D, 0.12±0.10 mm, p<0.001) years.Changes in SER and AL in both groups over that period were significantly less than in the historical control group (DIMS vs historical control: mean difference=-0.18±0.42D, p=0.012; 0.08±0.15 mm, p=0.001; Control-to-DIMS versus historical control: adjusted mean differences=-0.30±0.42D, p<0.001; 0.12±0.16 mm, p<0.001).
Myopia control effect was sustained in the third year in children who had used the DIMS spectacles in the previous 2 years and was also shown in the children switching from SV to DIMS lenses.
在为期两年的近视控制试验后，继续佩戴离焦多焦点（DIMS）镜片或从单焦点（SV）切换到 DIMS 镜片的儿童中，确定近视进展情况。
共有 128 名儿童参与了这项研究。戴 DIMS 镜片的儿童继续戴 DIMS 镜片（DIMS 组），戴 SV 镜片的儿童改为戴 DIMS 镜片（从 SV 切换到 DIMS 组）。每隔 6 个月测量睫状肌麻痹等效球镜（SER）和眼轴（AL）。将历史对照组与 DIMS 组在 24 个月时按年龄匹配，用于比较第三年的变化。
在 3 年期间，DIMS 组（n=65）的 SER 和 AL 变化分别为-0.52±0.69D 和 0.31±0.26mm；随着时间的推移，这些变化没有统计学意义（重复测量方差分析，p>0.05）。第三年，从 SV 切换到 DIMS 组（n=55）的 SER（-0.04±0.38D）和 AL（0.08±0.12mm）变化小于第一年（平均差值=0.45±0.30D，0.21±0.11mm，p<0.001）和第二年（0.34±0.30D，0.12±0.10mm，p<0.001）。在此期间，两组的 SER 和 AL 变化均明显小于历史对照组（DIMS 与历史对照组：平均差值=-0.18±0.42D，p=0.012；0.08±0.15mm，p=0.001；从 SV 切换到 DIMS 与历史对照组：调整后的平均差值=-0.30±0.42D，p<0.001；0.12±0.16mm，p<0.001）。
在过去 2 年中使用 DIMS 眼镜的儿童在第三年保持了近视控制效果，从 SV 切换到 DIMS 镜片的儿童也显示出了这种效果。
