丙戊酸过量导致高氨血症性脑病。
Valproate overdose leading to hyperammonaemic encephalopathy.
机构信息
Anaesthesia and Critical Care Medicine, Sandwell and West Birmingham NHS Trust, Birmingham, UK
Department of Emergency Medicine, Sandwell and West Birmingham Hospitals NHS Trust, Birmingham, UK.
出版信息
BMJ Case Rep. 2023 Jul 9;16(7):e255319. doi: 10.1136/bcr-2023-255319.
Sodium valproate is a commonly prescribed anticonvulsant medication; however, it can cause uncommon side effects such as hyperammonaemia and encephalopathy. We present the case of a male in his early 50s brought to the emergency department after being found collapsed by his wife, with an empty bottle of sodium valproate tablets. The patient developed hyperammonaemic encephalopathy due to sodium valproate overdose and was treated with supportive care and renal replacement therapy. This case highlights the importance of recognising the potential complications of sodium valproate and its prompt treatment.
丙戊酸钠是一种常用的抗惊厥药物；然而，它也会引起一些罕见的副作用，如高血氨症和脑病。我们报告了一例 50 多岁的男性，被妻子发现昏倒在急诊室，旁边有一个丙戊酸钠片的空瓶子。该患者因丙戊酸钠过量而发生高氨血症性脑病，并接受了支持性治疗和肾脏替代治疗。本病例强调了识别丙戊酸钠潜在并发症及其及时治疗的重要性。
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