Department of Experimental Dentistry, Wroclaw Medical University, Wroclaw, Poland.
Department and Clinic of Internal Medicine, Occupational Diseases, Hypertension and Clinical Oncology, Wroclaw Medical University, Wroclaw, Poland.
J Oral Rehabil. 2022 Apr;49(4):422-429. doi: 10.1111/joor.13295. Epub 2021 Dec 21.
Sleep bruxism (SB) is a complex behaviour that seems to be associated with the serotoninergic pathway.
This exploratory research aimed to evaluate the levels of serotonin in individuals with sleep bruxism diagnosed by video polysomnography. The study also evaluated whether the levels of serotonin were associated with body mass index, heart rate, and sleep parameters.
The study participants were adults hospitalised in the Department and Clinic of Internal Medicine, Occupational Diseases, Hypertension and Clinical Oncology at the Wroclaw Medical University. They underwent a single-night video polysomnography during which sleep and SB parameters and heart rate were evaluated. Additionally, body mass index and blood serotonin levels were evaluated for each patient.
A total of 105 patients were included in this study (80 women and 25 men). All the patients were Caucasians aged 18-63 years, with a mean age ± (standard deviation) of 33.43± 10.8 years. Seventy-five patients (71.43%) presented sleep bruxism (bruxism episodes index ≥2) and 30 (28.57%) did not. Fifty patients (47.62%) presented severe sleep bruxism (bruxism episodes index >4). The results showed that lower blood serotonin levels were associated with severe sleep bruxism; increased bruxism episodes index, rapid eye movement sleep, and body mass index; and decreased maximal pulse.
Severe sleep bruxism and the associated phenomena seem to co-occur with lower blood serotonin levels. The study supports the hypothesis on the relationship between the serotoninergic pathway and sleep bruxism.
睡眠磨牙症（SB）是一种复杂的行为，似乎与 5-羟色胺能途径有关。
本探索性研究旨在评估通过视频多导睡眠图诊断为睡眠磨牙症的个体中 5-羟色胺的水平。该研究还评估了 5-羟色胺水平是否与体重指数、心率和睡眠参数相关。
研究参与者为在弗罗茨瓦夫医科大学内科、职业病、高血压和临床肿瘤学系和诊所住院的成年人。他们接受了一次单夜视频多导睡眠图检查，在此期间评估了睡眠和 SB 参数以及心率。此外，还评估了每位患者的体重指数和血液 5-羟色胺水平。
共有 105 名患者纳入本研究（80 名女性和 25 名男性）。所有患者均为 18-63 岁的白种人，平均年龄±（标准差）为 33.43±10.8 岁。75 名患者（71.43%）存在睡眠磨牙症（磨牙症发作指数≥2），30 名患者（28.57%）不存在。50 名患者（47.62%）存在严重睡眠磨牙症（磨牙症发作指数>4）。结果表明，较低的血液 5-羟色胺水平与严重睡眠磨牙症、磨牙症发作指数增加、快速眼动睡眠和体重指数增加以及最大脉搏减少有关。
严重的睡眠磨牙症及其相关现象似乎与较低的血液 5-羟色胺水平同时发生。该研究支持了 5-羟色胺能途径与睡眠磨牙症之间存在关联的假说。
