Heng Xuan, Pan Yuhao, Chen Xinghui, Pu Liuyi, Lu Jiaping, Li Ka, Tang Kangjian
Innovation Center for Chemical Sciences, College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou 215123, People's Republic of China.
Dental Clinic of Xuhui District, Shanghai 200031, People's Republic of China.
ACS Omega. 2023 Jun 17;8(26):23936-23944. doi: 10.1021/acsomega.3c02428. eCollection 2023 Jul 4.
Chronic oral diseases are boring, long-term, and discomfort intense diseases, which endanger the physical and mental health of patients constantly. Traditional therapeutic methods based on medicines (including swallowing drugs, applying ointment, or injection in situ) bring much inconvenience and discomfort. A new method possessing accurate, long-term, stable, convenient, and comfortable features is in great need. In this study, we demonstrated a development of one spontaneous administration for the prevention and therapy on a series of oral diseases. By uniting dental resin and medicine-loaded mesoporous molecular sieve, nanoporous medical composite resin (NMCR) was synthesized by a simple physical mixing and light curing method. Physicochemical investigations of XRD, SEM, TEM, UV-vis, N adsorption, and biochemical experiments of antibacterial and pharmacodynamic evaluation on periodontitis treatment of SD rats were carried on to characterize an NMCR spontaneous medicine delivery system. Compared to existing pharmacotherapy and in situ treatments, NMCR can keep a quite long time of stable in situ medicine release during the whole therapeutic period. Taking the periodontitis treatment as an instance, the probing pocket depth value in a half-treatment time of 0.69 from NMCR@MINO was much lower than that of 1.34 from the present commercial Periocline ointment, showing an over two times effect.
慢性口腔疾病是令人厌烦、病程漫长且不适强烈的疾病，不断危及患者的身心健康。基于药物的传统治疗方法（包括吞服药物、涂抹药膏或局部注射）带来诸多不便和不适。迫切需要一种具有精准、长效、稳定、便捷和舒适特点的新方法。在本研究中，我们展示了一种用于预防和治疗一系列口腔疾病的自发给药方法的进展。通过将牙科树脂与载药介孔分子筛结合，采用简单的物理混合和光固化方法合成了纳米多孔医用复合树脂（NMCR）。进行了XRD、SEM、TEM、UV-vis、N吸附等物理化学研究以及对SD大鼠牙周炎治疗的抗菌和药效学评价等生化实验，以表征NMCR自发给药系统。与现有的药物治疗和局部治疗相比，NMCR在整个治疗期间能保持相当长时间的稳定局部药物释放。以牙周炎治疗为例，NMCR@MINO在治疗时间一半时的探诊深度值为0.69，远低于目前市售的派丽奥软膏的1.34，显示出两倍多的效果。
