Reddy Akshay, Hosseini Mohammad Reza, Patel Aashay, Sharaf Ramy, Reddy Vishruth, Tabarestani Arman, Lucke-Wold Brandon
College of Medicine, University of Florida, USA.
Feinberg School of Medicine, Northwestern University, USA.
AIMS Neurosci. 2023 Apr 26;10(2):87-108. doi: 10.3934/Neuroscience.2023007. eCollection 2023.
Procedures for neurological disorders such as Parkinsons Disease (PD), Essential Tremor (ET), Obsessive Compulsive Disorder (OCD), Tourette's Syndrome (TS), and Major Depressive Disorder (MDD) tend to overlap. Common therapeutic procedures include deep brain stimulation (DBS), lesioning, and focused ultrasound (FUS). There has been significant change and innovation regarding targeting mechanisms and new advancements in this field allowing for better clinical outcomes in patients with severe cases of these conditions. In this review, we discuss advancements and recent discoveries regarding these three procedures and how they have led to changes in utilization in certain conditions. We further discuss the advantages and drawbacks of these treatments in certain conditions and the emerging advancements in brain-computer interface (BCI) and its utility as a therapeutic for neurological disorders.
帕金森病(PD)、特发性震颤(ET)、强迫症(OCD)、妥瑞氏症(TS)和重度抑郁症(MDD)等神经系统疾病的治疗程序往往相互重叠。常见的治疗程序包括深部脑刺激(DBS)、损伤和聚焦超声(FUS)。在该领域,靶向机制和新进展发生了重大变化和创新,使这些疾病严重病例的患者能获得更好的临床结果。在本综述中,我们讨论了关于这三种治疗程序的进展和最新发现,以及它们如何导致某些情况下治疗方法使用的变化。我们还讨论了这些治疗方法在某些情况下的优缺点,以及脑机接口(BCI)的新兴进展及其作为神经系统疾病治疗手段的效用。