Instituto de Química, Universidade Federal de Goiás, Goiânia, Brazil.
Instituto de Química, Universidade Estadual de Campinas (UNICAMP), Campinas, Brazil.
Nat Prod Res. 2024 Jun;38(12):2118-2122. doi: 10.1080/14786419.2023.2233672. Epub 2023 Jul 10.
Mart. is a plant popularly used in folk medicine by traditional communities from Brazilian savannah to treat general inflammation. According to ethnopharmacological data, this specie can be considered a source of biologically active molecules for the development of new drugs. Thereby, this study reports the results of the dereplication approach of roots extracts and the evaluation of its potential antinociceptive and anti-inflammatory in albino Swiss mice. Based on HPLC coupled to Q-Exactive Orbitrap Mass Spectrometer and using GNPS, a total of thirteen polyphenolic compounds were noticed, including four compounds that have been reported for the first time in the genus . Ethanolic and aqueous roots extracts demonstrated a dose-dependent inhibition for the number of writes, reduced pain induced by formalin and hyperalgesia induced by carrageenan. These extracts also reduced paw edema, cell migration, and myeloperoxidase activity, with effects similar to indomethacin and dexamethasone drugs.
马黛是一种植物，在巴西草原的传统社区中，被民间医学广泛用于治疗一般性炎症。根据民族药理学的数据，这种物种可以被认为是开发新药的生物活性分子的来源。因此，本研究报告了对根提取物进行去重复处理的结果，并评估了其在白化瑞士小鼠中的潜在镇痛和抗炎作用。基于高效液相色谱-四极杆轨道阱质谱联用仪（HPLC-Q-Exactive Orbitrap Mass Spectrometer），并使用 GNPS，共发现了 13 种多酚类化合物，其中包括 4 种在该属中首次报道的化合物。乙醇和水提根提取物对抓握次数的抑制呈剂量依赖性，减少了福尔马林引起的疼痛和卡拉胶引起的痛觉过敏。这些提取物还减少了爪肿胀、细胞迁移和髓过氧化物酶活性，其作用与吲哚美辛和地塞米松等药物相似。
