• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

比较老鼠和人类的大脑。

Comparing mouse and human brains.

机构信息

Centre for Research in Neuroscience, Department of Medicine, The Research Institute of the McGill University Health Centre, Montreal, Canada.

Integrated Program in Neuroscience, McGill University, Montreal, Canada.

出版信息

Elife. 2023 Jul 10;12:e90017. doi: 10.7554/eLife.90017.

DOI:10.7554/eLife.90017
PMID:37428552
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10332809/
Abstract

Inhibitory circuit motifs in the mouse brain and the human brain are strikingly similar.

摘要

在小鼠大脑和人类大脑中,抑制性回路基元惊人地相似。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2815/10332809/d411f9b2eb89/elife-90017-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2815/10332809/d411f9b2eb89/elife-90017-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2815/10332809/d411f9b2eb89/elife-90017-fig1.jpg

相似文献

1
Comparing mouse and human brains.比较老鼠和人类的大脑。
Elife. 2023 Jul 10;12:e90017. doi: 10.7554/eLife.90017.
2
Alterations of specific cortical GABAergic circuits underlie abnormal network activity in a mouse model of Down syndrome.唐氏综合征小鼠模型中海马特定 GABA 能回路的改变导致异常的网络活动。
Elife. 2020 Aug 12;9:e58731. doi: 10.7554/eLife.58731.
3
Microglia Elimination Increases Neural Circuit Connectivity and Activity in Adult Mouse Cortex.小胶质细胞清除可增加成年小鼠大脑皮层的神经回路连接和活动。
J Neurosci. 2021 Feb 10;41(6):1274-1287. doi: 10.1523/JNEUROSCI.2140-20.2020. Epub 2020 Dec 30.
4
Phylogenetic variation in cortical layer II immature neuron reservoir of mammals.哺乳动物皮质层 II 未成熟神经元库的系统发育变异。
Elife. 2020 Jul 21;9:e55456. doi: 10.7554/eLife.55456.
5
New insights into anatomical connectivity along the anterior-posterior axis of the human hippocampus using quantitative fibre tracking.利用定量纤维追踪技术深入了解人类海马体前后轴的解剖连接。
Elife. 2022 Nov 8;11:e76143. doi: 10.7554/eLife.76143.
6
Light Up the Brain: The Application of Optogenetics in Cell-Type Specific Dissection of Mouse Brain Circuits.点亮大脑:光遗传学在小鼠脑回路的细胞类型特异性解析中的应用。
Front Neural Circuits. 2020 Apr 24;14:18. doi: 10.3389/fncir.2020.00018. eCollection 2020.
7
Mapping brain-wide excitatory projectome of primate prefrontal cortex at submicron resolution and comparison with diffusion tractography.以亚微米分辨率绘制灵长类前额叶皮层的全脑兴奋性投射组图谱,并与扩散轨迹进行比较。
Elife. 2022 May 20;11:e72534. doi: 10.7554/eLife.72534.
8
Intrinsic excitability mechanisms of neuronal ensemble formation.神经元集合形成的内在兴奋性机制。
Elife. 2022 May 4;11:e77470. doi: 10.7554/eLife.77470.
9
Cell Type-Specific Circuit Mapping Reveals the Presynaptic Connectivity of Developing Cortical Circuits.细胞类型特异性电路映射揭示发育中皮质电路的突触前连接性。
J Neurosci. 2016 Mar 16;36(11):3378-90. doi: 10.1523/JNEUROSCI.0375-15.2016.
10
Multiplex Neural Circuit Tracing With G-Deleted Rabies Viral Vectors.利用 G 缺失型狂犬病毒载体进行多重神经回路示踪。
Front Neural Circuits. 2020 Jan 10;13:77. doi: 10.3389/fncir.2019.00077. eCollection 2019.

引用本文的文献

1
AdipoRon as a Novel Therapeutic Agent for Depression: A Comprehensive Review of Preclinical Evidence.脂联素受体激动剂AdipoRon作为抑郁症的新型治疗药物:临床前证据的综合综述
Biomedicines. 2025 Jul 31;13(8):1867. doi: 10.3390/biomedicines13081867.
2
Understanding Duchenne muscular dystrophy-associated brain pathology.了解杜兴氏肌营养不良症相关的脑部病理。
Dis Model Mech. 2025 Jul 1;18(7). doi: 10.1242/dmm.052302. Epub 2025 Aug 1.
3
Dissection of Neurochemical Pathways Across Complexity and Scale.跨越复杂性和尺度的神经化学通路剖析

本文引用的文献

1
Target cell-specific synaptic dynamics of excitatory to inhibitory neuron connections in supragranular layers of human neocortex.人新皮层颗粒上层兴奋性神经元到抑制性神经元连接的靶细胞特异性突触动态。
Elife. 2023 May 30;12:e81863. doi: 10.7554/eLife.81863.
2
The plasticitome of cortical interneurons.皮质中间神经元的可塑性组。
Nat Rev Neurosci. 2023 Feb;24(2):80-97. doi: 10.1038/s41583-022-00663-9. Epub 2022 Dec 30.
3
Synaptic connectivity to L2/3 of primary visual cortex measured by two-photon optogenetic stimulation.通过双光子光遗传学刺激测量初级视皮层 L2/3 的突触连接。
J Neurochem. 2025 Jul;169(7):e70160. doi: 10.1111/jnc.70160.
4
Developmental mechanisms underlying pediatric epilepsy.小儿癫痫的发育机制。
Front Neurol. 2025 Jun 3;16:1586947. doi: 10.3389/fneur.2025.1586947. eCollection 2025.
5
Neural mechanisms balancing accuracy and flexibility in working memory and decision tasks.在工作记忆和决策任务中平衡准确性和灵活性的神经机制。
NPJ Syst Biol Appl. 2025 May 7;11(1):41. doi: 10.1038/s41540-025-00520-2.
6
Classifying Neuronal Cell Types Based on Shared Electrophysiological Information from Humans and Mice.基于人类和小鼠共享的电生理信息对神经元细胞类型进行分类。
Neuroinformatics. 2024 Oct;22(4):473-486. doi: 10.1007/s12021-024-09675-5. Epub 2024 Jul 8.
7
Quantitative Proteomics Reveal Region-Specific Alterations in Neuroserpin-Deficient Mouse Brain and Retina: Insights into Serpini1 Function.定量蛋白质组学揭示神经丝氨酸蛋白酶缺陷型小鼠脑和视网膜中的区域特异性改变:对Serpini1功能的深入了解。
Proteomes. 2024 Mar 14;12(1):7. doi: 10.3390/proteomes12010007.
8
Microphysiological Blood-Brain Barrier Systems for Disease Modeling and Drug Development.用于疾病建模和药物开发的微生理血脑屏障系统。
Adv Healthc Mater. 2024 Aug;13(21):e2303180. doi: 10.1002/adhm.202303180. Epub 2024 Mar 12.
9
Treatments and regulatory mechanisms of acoustic stimuli on mood disorders and neurological diseases.声学刺激对情绪障碍和神经疾病的治疗及调节机制。
Front Neurosci. 2024 Jan 5;17:1322486. doi: 10.3389/fnins.2023.1322486. eCollection 2023.
Elife. 2022 Jan 21;11:e71103. doi: 10.7554/eLife.71103.
4
Comparative cellular analysis of motor cortex in human, marmoset and mouse.人类、狨猴和小鼠运动皮层的比较细胞分析。
Nature. 2021 Oct;598(7879):111-119. doi: 10.1038/s41586-021-03465-8. Epub 2021 Oct 6.
5
Integrated Morphoelectric and Transcriptomic Classification of Cortical GABAergic Cells.皮质 GABA 能神经元的综合形态电和转录组分类
Cell. 2020 Nov 12;183(4):935-953.e19. doi: 10.1016/j.cell.2020.09.057.
6
Robust perisomatic GABAergic self-innervation inhibits basket cells in the human and mouse supragranular neocortex.在人类和小鼠的颗粒上层皮质中,强健的胞体 GABA 能自身传入抑制篮状细胞。
Elife. 2020 Jan 9;9:e51691. doi: 10.7554/eLife.51691.
7
Synaptic plasticity in human cortical circuits: cellular mechanisms of learning and memory in the human brain?人类皮质回路中的突触可塑性:人类大脑学习和记忆的细胞机制?
Curr Opin Neurobiol. 2019 Feb;54:186-193. doi: 10.1016/j.conb.2018.06.013. Epub 2018 Jul 13.
8
Excitatory/Inhibitory Balance and Circuit Homeostasis in Autism Spectrum Disorders.自闭症谱系障碍中的兴奋/抑制平衡与神经回路稳态
Neuron. 2015 Aug 19;87(4):684-98. doi: 10.1016/j.neuron.2015.07.033.
9
Target-cell-specific short-term plasticity in local circuits.局部回路中靶细胞特异性短期可塑性。
Front Synaptic Neurosci. 2013 Dec 6;5:11. doi: 10.3389/fnsyn.2013.00011.