Key Laboratory for Palygorskite Science and Applied Technology of Jiangsu Province, Huaiyin Institute of Technology, Huai'an 223003, PR China; National Engineering Research Center for Modernization of Traditional Chinese Medicine, Guangzhou University of Chinese Medicine, Guangzhou 510006, PR China.
Affiliated Huai'an Hospital of Xuzhou Medical University, Huai'an 223002, PR China.
Int J Biol Macromol. 2023 Aug 30;247:125727. doi: 10.1016/j.ijbiomac.2023.125727. Epub 2023 Jul 8.
Drug delivery systems have emerged as a prominent research focus in the field of drug development, offering enhanced stability and improved bioavailability. Among them, protein (silk, gelatin and whey) or polysaccharide (alginate, chitosan, cellulose, starch, pectin and carrageenan) aerogels derived from natural sources have gained increasing popularity due to their unique advantages, such as cost-effectiveness, flexible preparation, bioactivity, biocompatibility, and biodegradability. However, despite their growing significance, there remains a lack of comprehensive information and ongoing confusion regarding the application of protein/polysaccharide aerogels in drug delivery system. Hence, the objective of this review was to provide a comprehensive review of the research progress in protein/polysaccharide aerogels for drug delivery systems from the perspective of aerogels category, synthesis strategy, drug-loading method, performance characteristic and release mechanism. Furthermore, by consolidating the existing information, we aimed to present our own perspectives and insights on the future development of protein/polysaccharide aerogels in drug delivery system. In conclusion, this comprehensive review served as a valuable resource for researchers and scholars, addressing the current gaps in knowledge and clarifying the complex landscape of protein/polysaccharide aerogels in drug delivery system.
药物输送系统已成为药物开发领域的一个重要研究焦点，提供了增强的稳定性和改善的生物利用度。在这些系统中，源自天然来源的蛋白质（丝蛋白、明胶和乳清）或多糖（海藻酸盐、壳聚糖、纤维素、淀粉、果胶和卡拉胶）气凝胶由于其独特的优势，如成本效益、灵活的制备、生物活性、生物相容性和可生物降解性，越来越受到关注。然而，尽管它们的重要性日益增加，但在蛋白质/多糖气凝胶在药物输送系统中的应用方面，仍然缺乏全面的信息和持续的混淆。因此，本综述的目的是从气凝胶类别、合成策略、载药方法、性能特征和释放机制等方面，对蛋白质/多糖气凝胶在药物输送系统中的研究进展进行全面综述。此外，通过整合现有的信息，我们旨在对蛋白质/多糖气凝胶在药物输送系统中的未来发展提出自己的观点和见解。总之，本综述为研究人员和学者提供了有价值的资源，解决了目前知识上的差距，并阐明了蛋白质/多糖气凝胶在药物输送系统中的复杂情况。
