Center for Influenza and Emerging Infectious Diseases, University of Missouri, Columbia, MO, USA.
Department of Molecular Microbiology and Immunology, School of Medicine, University of Missouri, Columbia, MO, USA.
Nat Commun. 2023 Jul 10;14(1):4078. doi: 10.1038/s41467-023-39782-x.
SARS-CoV-2 is a zoonotic virus with documented bi-directional transmission between people and animals. Transmission of SARS-CoV-2 from humans to free-ranging white-tailed deer (Odocoileus virginianus) poses a unique public health risk due to the potential for reservoir establishment where variants may persist and evolve. We collected 8,830 respiratory samples from free-ranging white-tailed deer across Washington, D.C. and 26 states in the United States between November 2021 and April 2022. We obtained 391 sequences and identified 34 Pango lineages including the Alpha, Gamma, Delta, and Omicron variants. Evolutionary analyses showed these white-tailed deer viruses originated from at least 109 independent spillovers from humans, which resulted in 39 cases of subsequent local deer-to-deer transmission and three cases of potential spillover from white-tailed deer back to humans. Viruses repeatedly adapted to white-tailed deer with recurring amino acid substitutions across spike and other proteins. Overall, our findings suggest that multiple SARS-CoV-2 lineages were introduced, became enzootic, and co-circulated in white-tailed deer.
SARS-CoV-2 是一种人畜共患病病毒，有记录表明其在人和动物之间存在双向传播。由于变异株可能持续存在和进化，SARS-CoV-2 从人类传播到自由放养的白尾鹿（Odocoileus virginianus）可能会造成独特的公共卫生风险。我们于 2021 年 11 月至 2022 年 4 月期间，从美国华盛顿特区和 26 个州的自由放养白尾鹿中收集了 8830 份呼吸道样本。我们获得了 391 个序列，并鉴定出 34 个 Pango 谱系，包括 Alpha、Gamma、Delta 和 Omicron 变体。进化分析表明，这些白尾鹿病毒至少来自人类的 109 次独立溢出，导致 39 例随后的鹿间本地传播和 3 例白尾鹿潜在溢出到人类的情况。病毒在刺突蛋白和其他蛋白上反复适应白尾鹿，出现了反复的氨基酸替换。总的来说，我们的研究结果表明，多种 SARS-CoV-2 谱系已被引入并在白尾鹿中定殖和共同传播。
Zotero 插件
